Immunology

Program affiliation
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
We investigate how the immune system maintains balance during healthy homeostasis, and when this balance is thrown off, how the dysregulated activities of the same immune cells cause immune diseases such as asthma, allergy and autoimmunity. We focus on type 2 lymphocytes, namely ILC2s and Th2 cells, and apply high-throughput CRISPR screens to identify novel regulators of type 2 immune responses. We are a multidisciplinary laboratory combining molecular, in vitro and in vivo approaches to understand the underlying mechanisms of immune cell function in homeostasis and allergic diseases. By advancing our basic understanding of how immune cells develop and function, we aim to develop novel approaches to restoring immune balance and promoting tissue and organismal health.

Key words
type 2 immunity, innate lymphoid cells, ILC2, Th2, allergy, asthma, CRISPR screen, computational, transcriptomic, epigenetic, tissue immunity, mucosal immunity, neuroimmune

Program affiliation
Immunology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
Our research focuses on employing multi-omics strategies to elucidate mechanisms of immune tolerance, identify novel targets for immunosuppression and develop precision approaches to immunosuppression management in advanced lung disease and lung transplantation.

Key words
immunology, genetics, T cell, neutrophil, transplant, pharmacogenetics, pharmacogenomics, immunogenetics, immunogenomics, clonal hematopoiesis, senescence, immune aging

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Immunology
Molecular Cell Biology
Neurosciences

Research summary
Cancer-Stroma interactions in metastasis

Key words
cancer metastasis; tumor microenvironment, cancer immunology, CRISPR screen, quantitative biology

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Immunology

Research summary
Naive pluripotency, trophoblast development, and stem-cell-based embryo models

Key words

Program affiliation
Cancer Biology
Human and Statistical Genetics
Immunology
Molecular Genetics and Genomics

Research summary
Genomics of breast cancer etiology to identify targetable pathways

Key words
Genomics, biomarkers, metabolic imbalance, mammographic density, breast cancer, colorectal cancer, prevention,

Program affiliation
Immunology

Research summary
Receptor-mediated modulation of NK cell responses in vivo

Key words
innate immunity, NK cells, receptors, signal transduction, tolerance

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Immunology
Cancer Biology

Research summary
We want to understand how microbes interact with humans so that we can identify new strategies to improve health. Our research integrates 'skinomics', metagenomics and host-microbial genetics to address how microbes influence skin physiology.

Key words
microbiome, skin, dermatology, skin diseases, infection, skin cancer, wound healing, environmental exposures

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Cytokine-mediated tissue feedback loops that maintain homeostasis, and environmental factors that instigate inflammation and fibrosis.

Key words

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology
Cancer Biology

Research summary
The bone microenvironment for cancer and infection

Key words
bone biology, osteoclast, cancer, metastasis, osteoporosis, microenvironment, osteoblast, osteomyelitis, infection

Program affiliation
Immunology
Neurosciences
Molecular Cell Biology

Research summary
The Walsh lab is interested in how the immune system is involved in both normal and pathological processes in the eye, exploring the contribution of both local immune cells and systemic immunity on ocular functioning.

Key words
Autoimmunity, CD4 T cell biology, Uveitis, CNS border immunology, Translational Research