Molecular Cell Biology

Program affiliation
Molecular Cell Biology

Research summary
We aim to identify cellular and molecular mechanisms in the novel and rapidly expanding field of interorgan crosstalk in health and disease.

Key words

Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science

Research summary
Molecular, cellular and circuit analysis of circadian rhythms in mammals

Key words
neurobiology, behavior, imaging, circadian rhythm, glia, brain cancer, potassium channels, neuropeptides, astrocytes, glioblastoma, cancer, developmental biology, computational modeling

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Utilization of genomic information from sarcomas to better understand the pathogenesis of these tumors and to identify biomarkers and therapeutic targets for these aggressive cancers.

Key words
sarcoma, metastasis, genomics, cell signalling, NF1, MPNST

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Understand how function is encoded into disordered sequences using a combination of computational and experimental approaches

Key words
Disordered proteins, IDPs, IDRs, phase transitions, emergence, deep learning, AI, bird-themed software packages

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Cellular and Molecular studies of Alzheimer’s disease

Key words
amyloid, tau, antibodies, apolipoprotein E, Alzheimer’s disease, neurodegeneration, neurobiology

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
New drugs for post-viral and related types of disease

Key words
drug discovery, innate immunity, epithelial stem cells, viruses, respiratory airway disease

Program affiliation
Molecular Cell Biology

Research summary
Our lab studies airway and motile cilia biology and investigates the effects of mutations on cilia function

Key words
cilia, PCD, airway, lung

Program affiliation
Molecular Cell Biology

Research summary
Structural Biology and Regulation of Glucose Transport; Molecular Mechanisms Leading to Insulin Resistance

Key words
protein structure, glucose transport, diabetes, AIDS, HIV therapy, membrane protein, structural biology, heart, affinity labeling, drug design

Program affiliation
Neurosciences
Molecular Cell Biology
Computational and Systems Biology

Research summary
Our lab deciphers how fruit flies learn, memorize, and make decisions using state-of-the-art optical imaging techniques

Key words
Voltage imaging, computational modeling, learning system, memory processing, Drosophila melanogaster

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Interdisciplinary approach combining genetics, genomics, biochemistry, structural biology, high-resolution imaging, animal models, clinical studies and combinatorial chemistry to determine key aspects of bacterial pathogenesis and apply our knowledge to development of new therapeutics.

Key words
antibiotic-sparing therapeutics, host-pathogen interactions, bacterial pathogenesis, drug and vaccine development, multi-drug resistant E. coli, MRSA, Enterococcus, Acinetobacter, Klebsiella, urinary tract infections (UTI)