Molecular Cell Biology

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
we study the molecular mechanisms that regulate the architecture, dimensions and dynamics of actin filament networks, and tune them to support essential cellular functions including cell migration, intracellular trafficking and cytokinesis.

Key words
actin cytoskeleton, microtubule, single molecule, live cell imaging, protein transport, Golgi, confocal microscopy

Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary

Key words

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Cancer Biology

Research summary
I am interested in precursor conditions or metaplasias in the stomach and esophagus (i.e Barrett’s esophagus) as these lesions are key to understanding the formation of gastroesophageal adenocarcinomas.

Key words
Intestinal metaplasia, gastroesophageal cancer, Barrett's esophagus, GI development, Organoids

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Immunology

Research summary
Molecular mechanisms of skeletal and cardiac muscle development and disease

Key words
muscle, congenital disease, organogenesis, gene discovery

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Immunology

Research summary
Decoding cell fate decision mechanisms to modulate lineage output for therapeutic purpose

Key words
Hematopoietic stem cells, Multipotent progenitors, Cell fate decision, Lineage specification, Stem cell biology, Cancer (myeloid leukemia), Aging

Program affiliation
Cancer Biology
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
A major component of my research program is to (1) develop strategies for improving the therapeutic ratio of radiation therapy by increasing tumor sensitivity to radiation and limiting normal tissue toxicity and (2) understand the biological mechanisms of treatment resistance.

Key words
Cancer targeting, antibodies, Translational research, Radiation, Lung Cancer, Glioblastoma, Signaling mechanisms

Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary

Key words
tumor growth, metastasis, signaling mechanisms, immunology, cancer, B cells, Tregs

Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the molecular and cellular mechanisms underlying tauopathies

Key words
neurodegeneration, neurogenetics, Alzheimer`s disease, frontotemporal dementia, tau, amyloid precursor protein, induced pluripotent stem cells (iPSC), cell and molecular biology, molecular mechanisms

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understand fundamental cellular and molecular mechanisms that drive the biogenesis and dynamics of intracellular membrane compartments

Key words
cytoskeleton, membranes, intracellular trafficking, organelle biogenesis, fluorescence, crystallography

Program affiliation
Developmental Regenerative and Stem Cell Biology
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding and modifying the mechanisms controlling the onset of melanoma cancer by integrating zebrafish models and human disease

Key words
melanoma, cancer initiation, epigenetics, molecular genetics, neural crest, zebrafish, cancer models