Molecular Cell Biology
Stephen Oh, MD, PhD
Professor
- Email: stoh@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Immunology
Research summary
Mechanisms of dysregulated signaling in blood cancers
Key words
cancer biology, signal transduction, JAK2, leukemia, hematopoiesis, stem cells, mass cytometry, CyTOF, genomics
John Olson Jr., MD, PhD
William K. Bixby Professor and Head of the Department of Surgery
- Email: jaolson@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Research summary
Understanding endocrine tumor formation
Key words
David Ornitz, MD, PhD
Alumni Endowed Professor
- Email: dornitz@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Neurosciences
Research summary
Regulation of lung, skeletal, and cardiovascular development, injury response, and regeneration by Fibroblast Growth Factors
Key words
cell signaling; development; fibroblast growth factors; mouse models; stem cells, regeneration; pulmonary hypertension; alveologenesis; endocrine signaling
Miranda Orr, PhD
Associate Professor
- Email: orr.m@wustl.edu
Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Computational and Systems Biology
Immunology
Research summary
Key words
Philip Osdoby, PhD
Professor
- Email: osdoby@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
Bone remodeling cell and molecular events of osteoclast activity and development
Key words
extracellular matrix, bone biology, development, aging, osteoclast
B. Duygu Ozpolat, PhD
Assistant Professor
- Email: bdozpolat@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Plant and Microbial Biosciences
Research summary
Mechanisms of reproductive cell regeneration and development
Key words
germline, reproduction, stem cells, regeneration, imaging, scRNAseq
Russell Pachynski, MD
Associate Professor
- Email: rkpachynski@wustl.edu
Program affiliation
Cancer Biology
Immunology
Molecular Cell Biology
Research summary
Key words
Dave Pagliarini, PhD
Hugo F. and Ina C. Urbauer Professor
- Email: pagliarini@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.
Key words
Mitochondria, Protein biochemistry, Genetic screening, Metabolism, Biosynthesis, Orphan protein function, Proteomics, Metabolomics, Kinases and phosphates, Metabolic disease, Systems biochemistry
Amit Pathak, PhD
Associate Professor
- Email: pathaka@wustl.edu
Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
We combine experimental measurements and computational modeling to understand how single and grouped respond to physical heterogeneities present in their extracellular microenvironments.
Key words
Mechanobiology; tumor invasion; cell migration; epithelial-mesenchymal transition; cell-matrix interaction; cytoskeleton;
David Perlmutter, MD
Spencer T. and Ann W. Olin Distinguished Professor
- Email: perlmutterd@wustl.edu
Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics
Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins
Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs