Molecular Genetics and Genomics

Program affiliation
Immunology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
Our research focuses on employing multi-omics strategies to elucidate mechanisms of immune tolerance, identify novel targets for immunosuppression and develop precision approaches to immunosuppression management in advanced lung disease and lung transplantation.

Key words
immunology, genetics, T cell, neutrophil, transplant, pharmacogenetics, pharmacogenomics, immunogenetics, immunogenomics, clonal hematopoiesis, senescence, immune aging

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Immunology
Molecular Cell Biology
Neurosciences

Research summary
Cancer-Stroma interactions in metastasis

Key words
cancer metastasis; tumor microenvironment, cancer immunology, CRISPR screen, quantitative biology

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Immunology

Research summary
Naive pluripotency, trophoblast development, and stem-cell-based embryo models

Key words

Program affiliation
Cancer Biology
Human and Statistical Genetics
Immunology
Molecular Genetics and Genomics

Research summary
Genomics of breast cancer etiology to identify targetable pathways

Key words
Genomics, biomarkers, metabolic imbalance, mammographic density, breast cancer, colorectal cancer, prevention,

Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Epigenetic regulation of phenotypes by propagation of prions in yeast

Key words
amyloid, chaperones, epigenetics, neurodegeneration, prion, yeast

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Molecular Genetics and Genomics
Neurosciences

Research summary
Discovery and characterization of genetic etiological factors involved in neurodevelopmental disorders

Key words
genomics, genetics, autism, neurodevelopmental disorders, complex disease, noncoding, enhancers, whole-genome sequencing, whole-exome sequencing, single-nucleotide variation, insertions/deletions, copy number variation, structural variation

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Immunology
Cancer Biology

Research summary
We want to understand how microbes interact with humans so that we can identify new strategies to improve health. Our research integrates 'skinomics', metagenomics and host-microbial genetics to address how microbes influence skin physiology.

Key words
microbiome, skin, dermatology, skin diseases, infection, skin cancer, wound healing, environmental exposures

Program affiliation
Plant and Microbial Biosciences
Molecular Genetics and Genomics

Research summary
Cell growth, size control and evolution of sex in Volvocine algae

Key words
evolution, cell biology, developmental biology, size control, cell division, sexual dimorphism

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Regenerative and Gene Therapy for Wolfram Syndrome, a Prototype Endoplasmic Reticulum Disorder

Key words
Wolfram syndrome, Diabetes, Vision Loss, Hearing Loss, Neurodegeneration, Gene Therapy, Genetics, Endoplasmic Reticulum

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding the metabolism of sarcomas for therapeutic development

Key words
Cancer, Metabolism, Human in mouse Cancer Models, New Therapies, Tumor Models, Metobolomics, Mouse Genetics