Molecular Genetics and Genomics

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
My research program studies DNA methylation in cancer, with a specific emphasis on understanding the origin, evolution, and functional impact of cancer-associated DNA methylation changes and how these can be used as biomarkers of clinical outcomes.

Key words
epigenetics, methylation, gene regulation, cancer, leukemia, genomics

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Examining the role the tumor microenvironment plays in immune modulation, tumor development, metastasis and dormancy

Key words
aging, cancer, microenvironment, RNAi, senescence, telomere

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
We use multiomic approaches to discover mechanisms underlying cardiovascular disease and leverage these insights to identify new drug targets.

Key words
Human genetics; cardiovascular disease

Program affiliation
Ecology and Evolutionary Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences

Research summary
We work on social interactions and mutualism using a microbial system so we can study cheating, conflict and cooperation at experimental and genomic levels, within and between species, in particular in social amoebae and their farmed bacteria

Key words
social evolution; multicellularity; mutualism; symbiosis; experimental evolution; disease; social amoebae; Dictyostelium; science education; birds

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
The Stratman lab is broadly interested in how blood vessels form and stabilize during development, and how changes in these processes affect tissue homeostasis and disease.

Key words
mechanobiology, vascular, endothelial cell, blood flow

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Biomedical Informatics and Data Science
Molecular Genetics and Genomics

Research summary

Key words
protein design, protein engineering, influenza, RSV, machine learning , vaccines, antivirals

Program affiliation
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
We investigate how the immune system maintains balance during healthy homeostasis, and when this balance is thrown off, how the dysregulated activities of the same immune cells cause immune diseases such as asthma, allergy and autoimmunity. We focus on type 2 lymphocytes, namely ILC2s and Th2 cells, and apply high-throughput CRISPR screens to identify novel regulators of type 2 immune responses. We are a multidisciplinary laboratory combining molecular, in vitro and in vivo approaches to understand the underlying mechanisms of immune cell function in homeostasis and allergic diseases. By advancing our basic understanding of how immune cells develop and function, we aim to develop novel approaches to restoring immune balance and promoting tissue and organismal health.

Key words
type 2 immunity, innate lymphoid cells, ILC2, Th2, allergy, asthma, CRISPR screen, computational, transcriptomic, epigenetic, tissue immunity, mucosal immunity, neuroimmune

Program affiliation
Immunology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
Our research focuses on employing multi-omics strategies to elucidate mechanisms of immune tolerance, identify novel targets for immunosuppression and develop precision approaches to immunosuppression management in advanced lung disease and lung transplantation.

Key words
immunology, genetics, T cell, neutrophil, transplant, pharmacogenetics, pharmacogenomics, immunogenetics, immunogenomics, clonal hematopoiesis, senescence, immune aging

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Immunology
Molecular Cell Biology
Neurosciences

Research summary
Cancer-Stroma interactions in metastasis

Key words
cancer metastasis; tumor microenvironment, cancer immunology, CRISPR screen, quantitative biology

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental, Regenerative and Stem Cell Biology
Molecular Genetics & Genomics

Research summary

Key words