Neurosciences

Program affiliation
Neurosciences
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Applying concepts and methods from statistical physics and mathematics to the study of the brain

Key words
theoretical and computational neuroscience, statistical physics

Program affiliation
Cancer Biology
Neurosciences

Research summary
The mission of the Thompson Lab is to discover and target molecular drivers of leptomeningeal dissemination of malignant pediatric brain tumors and develop peptide vaccines targeting CMV antigens expressed in brain tumors.

Key words
pediatric brain tumor, medulloblastoma, vaccine, immunotherapy, leptomeningeal dissemination

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Molecular Genetics and Genomics
Neurosciences

Research summary
Discovery and characterization of genetic etiological factors involved in neurodevelopmental disorders

Key words
genomics, genetics, autism, neurodevelopmental disorders, complex disease, noncoding, enhancers, whole-genome sequencing, whole-exome sequencing, single-nucleotide variation, insertions/deletions, copy number variation, structural variation

Program affiliation
Neurosciences

Research summary
Cerebral cortex in humans and nonhuman primates: structure, function, connectivity, development, and evolution

Key words
neurobiology, vision, cerebral cortex, brain mapping, connectomics

Program affiliation
Immunology
Neurosciences
Molecular Cell Biology

Research summary
The Walsh Lab is dedicated to defining the immunological landscape of the eye and how this process goes awry in uveitis. We utilize molecular and systems-level approaches to understand how local immune cells and systemic immunity collaborate to maintain ocular homeostasis or drive pathology, with a particular interest in the communication between the gut, eye, and brain.

Key words
Autoimmunity, CD4 T cell biology, Uveitis, CNS border immunology, Translational Research

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Cancer Biology
Neurosciences

Research summary
We study how the major microtubule organizing center of animal cells, the centrosome, is formed and regulated to enable cell division and signaling

Key words
Centrosomes, cilia, microtubules, cytoskeleton, organelles, subcellular organization, cell dynamics, mitosis, cell cycle, cell biology, biochemistry

Program affiliation
Neurosciences

Research summary
Understanding the neural mechanisms and neural computations underlying cognition and social behavior

Key words

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology

Research summary
Mechanisms of development, injury and repair in the vertebrate auditory system

Key words
hearing, vestibular, sensory, development, regeneration, macrophage, microglia

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
The interplay between the ubiquitin-proteasome and autophagy pathways in skeletal muscle and neurodegenerative disorders

Key words
protein production and clearance, proteasome, skeletal muscle, inclusion body, autophagy

Program affiliation
Neurosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Elucidating the biological pathways underlying cognition, emotion, and behavior, determining developmental deviations and degenerative processes in these pathways

Key words