Programs

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Our current research focuses on delineating the cellular, molecular, and metabolic processes involved in the development of fibrotic disorders such as Idiopathic pulmonary fibrosis (IPF) and how these metabolic adaptations may in turn be targeted therapeutically for IPF.

Key words
Idiopathic pulmonary fibrosis (IPF), metabolic networks, targetable mechanisms driving fibroblast function and fibrosis

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Improve outcomes for patients with acute myeloid leukemia (AML) and other hematopoietic malignancies utilizing genomic and molecular biology techniques

Key words

Program affiliation
Cancer Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
Tryptophan metabolism and probiotic bacteria as modifiers of intestinal cancer and inflammation

Key words
tryptophan metabolism, intestinal inflammation, colitis associated cancer, colon cancer, mucositis, tryptophan, crohn, colitis, inflammatory bowel disease, radiation enteritis

Program affiliation
Neurosciences

Research summary
Relationship between synaptic activtity and amyloid-beta metabolism in Alzheimer`s disease

Key words
Alzheimer’s disease, drug and target discovery, endocytosis, in vivo microdialysis, synaptic transmission

Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Cancer Biology

Research summary
Connexins, cadherins in bone cell interactions with cancer and energy metabolism

Key words
bone biology, cell adhesion, signal transduction, gap junctions, cadherin

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics

Research summary
We study how dynamic transcriptional and epigenetic states regulate multipotent retinal progenitor cell neurogenesis and cell fate specification. Studies focus on identifying novel genes and processes that bias retinal development, including lncRNAs and DNA methylation status, using a suite of genomic tools. Integration of our studies with human genetics seeks to understand how genetic variants contribute to molecular dysfunction and manifest as inherited retinal disease.

Key words
Retina; development, lncRNA, DNA demethylation, transcription factors

Program affiliation
Immunology
Molecular Cell Biology

Research summary
The mechanisms regulating calcium-dependent neutrophil activation

Key words

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Genomic analyses of regulatory networks, Non-coding disease variants

Key words
Genomics, Genetic Variation, High-Throughput Technologies, Single-Cell Regulatory Genomics, Computational Biology

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology
Molecular Genetics and Genomics

Research summary
Causes and prevention of breast cancer, premalignant lesions, risk stratification

Key words
breast cancer, cancer, genetic epidemiology, hormones, obesity, obesity and malnutrition

Program affiliation
General

Research summary
Molecular mechanisms of cell motility and cytoskeleton assembly

Key words
cell motility, cytoskeleton, actin, intermediate filament, microtubules, septin, cell migration