Programs

Program affiliation
Neurosciences
Cancer Biology
Computational and Systems Biology

Research summary
Our lab employs cutting-edge molecular biology techniques to investigate the genetic, epigenetic, and cellular alterations driving the initiation, progression, and therapeutic resistance of brain tumors.

Key words
brain tumors, systems biology, genetics, neurosurgery, neurooncology

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
We combine experimental measurements and computational modeling to understand how single and grouped respond to physical heterogeneities present in their extracellular microenvironments.

Key words
Mechanobiology; tumor invasion; cell migration; epithelial-mesenchymal transition; cell-matrix interaction; cytoskeleton;

Program affiliation
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
To understand the metabolic crosstalk between cells and tissues in disease models such as cancer by using isotopes and metabolomics

Key words
metabolism, metabolomics, mass spectrometry, bioinformatics, imaging, cancer, tumor microenvironment, isotope tracing

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
Identifying new targets and possible therapies to treat malaria

Key words
malaria, mRNA surveillance, drug discovery

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Translational Bioinformatics, Clinical Research Informatics

Key words
Biomedical Informatics, Data Science, Data Analytics, Clinical Research, Translational Research

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Biomedical Informatics and Data Science
Molecular Microbiology and Microbial Pathogenesis

Research summary
Epigenomic aberrations in B cell lymphomas and their impact on gene regulation

Key words
epigenomics, cancer, lymphoma, histone, informatics, genomics, gene regulation

Program affiliation
Ecology and Evolutionary Biology
Plant and Microbial Biosciences

Research summary
The ecology and evolution of infectious diseases, with a focus on wild populations of herbaceous plant hosts and their powdery mildew pathogens.

Key words
host-parasite interactions, disease ecology, plant pathogens, urban ecology, climate change

Program affiliation
Immunology
Cancer Biology
Neurosciences

Research summary
Understanding the role of immune system in the pathogenesis of cancer and age-related neurological disorders (Alzheimer's disease), and then to develop effective strategies for manipulation of immune cell fate and function for disease prevention and immunotherapy.

Key words
Senescent T cells, Regulatory T cells (Tregs), Dendritic cells (DCs), Tumor microenvironment, Alzheimer's disease, Cell metabolism, Toll-like receptors, Immunotherapy

Program affiliation
Neurosciences

Research summary

Key words

Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics

Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins

Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs