Programs

Program affiliation
General

Research summary
The Bigley lab studies the role of viruses in autoimmunity. We utilize animal models and human samples to explore the interplay between viruses, especially herpesviruses, and development of the immune system.

Key words
Autoimmunity, Virology, Herpesviruses

Program affiliation
Neurosciences
Biomedical Informatics and Data Science
Computational and Systems Biology

Research summary
Computational neuroimaging using big data to study brain organization and mental health

Key words
mental health, fMRI, connectivity, big data, psychiatry, computational models

Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
(1) Tourette syndrome neuroimaging; (2) Parkinson disease pharmacological imaging; (3) pharmacological activation neuroimaging

Key words
fMRI, neuroimaging, movement disorders, Tourette syndrome, pharmacology, PET, deep brain stimulation, DBS

Program affiliation
Plant and Microbial Biosciences
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis

Research summary
Interdisciplinary questions surrounding bacterial small molecule production

Key words
Streptomyces, biosynthesis, genome mining, antibiotics, regulation & genetics

Program affiliation
Molecular Cell Biology
Cancer Biology
Biochemistry Biophysics and Structural Biology

Research summary
Tumor cell biology, signal transduction, and drug development

Key words
cancer, signal transduction, molecular pharmacology, autophagy, metabolism, drug development

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
How genetic variation and environmental experience contribute to individual differences in brain function, behavior, and psychopathology

Key words

Program affiliation
General

Research summary
Placental and pituitary hormone genes

Key words
biochemistry, carbohydrate, protein structure, signal transduction, intracellular trafficking

Program affiliation
Computational and Systems Biology
Cancer Biology
Molecular Genetics and Genomics

Research summary
The interplay between inherited genetic variation, environmental factors, and acquired mutations in shaping the earliest stages of carcinogenesis

Key words
cancer, genetics, computational biology, genetic epidemiology

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
Emerging RNA viruses, vaccines, immunology

Key words
Host-pathogen interactions, Influenza virus, SARS-CoV-2, Bourbon virus, Viral pathogenesis, RNA biology, Influenza Reassortment

Program affiliation
General

Research summary
My research has focused on developing computational approaches to distilling and deciphering adaptive immune receptor sequences and tracking immune cell interaction through intracellular mitochondria transfer.

Key words
T Cell Receptor, TCR, B Cell Receptor, BCR, Computational Immunology, Adaptive Immunology, Machine Learning