Programs

Program affiliation
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
The Brimble lab studies the secondary consequences of viral gene therapy approaches. We primarily interrogate T cell responses arising in patients who have received AAV gene therapy and nucleic acid impurities of viral vector systems. We are also developing novel viral vector delivery systems immunologically distinct from AAV vectors in current clinical use.

Key words
AAV Gene Therapy TCR viral vectors translational

Program affiliation
Molecular Cell Biology

Research summary
Molecular and genetic mechanisms of airway epithelial cell differentiation and ciliogenesis

Key words
cilia, cilia diseases, lung development, airway disease, lung,

Program affiliation
General

Research summary
We focus on the intersection of metabolism and stress responses in human health and disease. We use basic and translational approaches to identify and investigate key metabolic regulators in both physiologic and pathophysiologic contexts including obesity and diabetes.

Key words
Metabolism, skeletal muscle, ER stress, calcium, mitochondria, SREBP, obesity, diabetes

Program affiliation
Cancer Biology

Research summary
We are interested in the neurodevelopmental and environmental factors that affect the risk of brain tumor development and cognitive impairment in children.

Key words
pediatric, glioma, obesity, neurofibromatosis, neurodevelopment

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology

Research summary

Key words

Program affiliation
Neurosciences

Research summary
Understanding the large-scale cortical electrophysiology that governs uniquely human behavior and cognition

Key words

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
The research in my laboratory is aimed at understanding fundamental principles of the interaction between bacterial pathogens and the human host.

Key words

Program affiliation
General

Research summary
Developing algorithms and architectures for large-scale biosequence comparison, genome annotation, and metagenomics

Key words
annotation, bioinformatics, computational biology, genome analysis, metagenomics

Program affiliation
Neurosciences
Biomedical Informatics and Data Science

Research summary
Our research is focussed on improving the design of neuroprosthetic systems for post-stroke rehabilitation by examining the relationship between neuroplasticity and motor recovery and the mechanisms of neuroprosthetic-driven neuroplasticity.

Key words
Neuroprosthetic, Brain-Computer Interface, Motor Control, Stroke, Neuroplasticity

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Molecular Biology of DNA replication and damage response in yeast and human

Key words
Cell cycle, DNA damage response, DNA replication, Checkpoints, Mutagenesis, DNA repair, yeast