Yiming Zhang

Program: Developmental Regenerative and Stem Cell Biology

Current advisor: Brian J. DeBosch, MD, PhD

Undergraduate university: University of Missouri-Columbia, 2015

Enrollment year: 2019

Research summary

Graduate publications
Zhang Y, Sun J, Wasserman HD, Adams JA, Higgins CB, Kelly SC, Lantier L, DeBosch BJ. 2024 A Structure-function Analysis of Hepatocyte Arginase 2 Reveals Mitochondrial Ureahydrolysis as a Determinant of Glucose Oxidation. Cell Mol Gastroenterol Hepatol, 17(5):801-20. PMCID: PMC10966292

Zhang Y, Higgins CB, Tica S, Adams JA, Sun J, Kelly SC, Zong X, Dietzen DJ, Pietka T, Ballentine SJ, Shriver L, Patti G, Cao Y, DeBosch BJ. 2024 Hierarchical tricarboxylic acid cycle regulation by hepatocyte arginase 2 links the urea cycle to oxidative metabolism. Cell Metab, ():Online ahead of print. PMCID:

Sun J, Zhang Y, Adams JA, Higgins CB, Kelly SC, Zhang H, Cho KY, Johnson UG, Swarts BM, Wada SI, Patti GJ, Shriver LP, Finck BN, Herzog ED, DeBosch BJ. 2024 Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock. Cell Rep, 43(10):114865. PMCID:

Higgins CB, Adams JA, Ward MH, Greenberg ZJ, Milewska M, Sun J, Zhang Y, Chiquetto Paracatu L, Dong Q, Ballentine S, Li W, Wandzik I, Schuettpelz LG, DeBosch BJ. 2023 The tetraspanin transmembrane protein CD53 mediates dyslipidemia and integrates inflammatory and metabolic signaling in hepatocytes. J Biol Chem, 299(2):102835. PMCID: PMC9900517

Higgins CB, Mayer AL, Zhang Y, Franczyk M, Ballentine S, Yoshino J, DeBosch BJ. 2022 SIRT1 selectively exerts the metabolic protective effects of hepatocyte nicotinamide phosphoribosyltransferase. Nat Commun, 13(1):1074. PMCID: PMC8885655

Zhang Y, Higgins CB, Van Tine BA, Bomalaski JS, DeBosch BJ. 2022 Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism. Cell Rep Med, 3(1):100498. PMCID: PMC8784773

Zhang Y, DeBosch B. 2022 A protocol to induce systemic autophagy and increase energy metabolism in mice using PEGylated arginine deiminase. STAR Protocols, 3(3):101489. PMCID: PMC9249829