Yun Chen

Program: Biochemistry, Biophysics, and Structural Biology

Current advisor: David M. Holtzman, MD

Undergraduate university: Nanjing Agricultural University, 2014

Enrollment year: 2018

Research summary

Graduate publications
Bigley TM, Xiong M, Ali M, Chen Y, Wang C, Serrano JR, Eteleeb A, Harari O, Yang L, Patel SJ, Cruchaga C, Yokoyama WM, Holtzman DM. 2022 Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains. Mol Neurodegener, 17(1):10.

Gratuze M, Chen Y, Parhizkar S, Jain N, Strickland MR, Serrano JR, Colonna M, Ulrich JD, Holtzman DM. 2021 Activated microglia mitigate Aβ-associated tau seeding and spreading. J Exp Med, 218(8):e20210542.

Molgora M, Esaulova E, Vermi W, Hou J, Chen Y, Luo J, Brioschi S, Bugatti M, Omodei AS, Ricci B, Fronick C, Panda SK, Takeuchi Y, Gubin MM, Faccio R, Cella M, Gilfillan S, Unanue ER, Artyomov MN, Schreiber RD, Colonna M. 2020 TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy. Cell, S0092-8674(20):30878-3.

Chen Y, Strickland MR, Soranno A, Holtzman DM. 2020 Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis. Neuron, ():S0896-6273(20)30776-5.