Yun Chen

Program: Biochemistry Biophysics and Structural Biology

Current advisor: David M. Holtzman, MD

Undergraduate university: Nanjing Agricultural University, 2014

Enrollment year: 2018

Research summary
ApoE Christchurch mutation in AD; ApoE-receptor interactions; CNS innate immunity in AD; CARM for AD

Graduate publications
Bigley TM, Xiong M, Ali M, Chen Y, Wang C, Serrano JR, Eteleeb A, Harari O, Yang L, Patel SJ, Cruchaga C, Yokoyama WM, Holtzman DM. 2022 Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains. Mol Neurodegener, 17(1):10. PMCID: PMC8760754

Chen Y, Colonna M. 2022 Two-faced behavior of microglia in Alzheimer’s disease. Nat Neurosci, 25(1):3-4

Wang S, Sudan R, Peng V, Zhou Y, Du S, Yuede CM, Lei T, Hou J, Cai Z, Cella M, Nguyen K, Poliani PL, Beatty WL, Chen Y, Cao S, Lin K, Rodrigues C, Ellebedy AH, Gilfillan S, Brown GD, Holtzman DM, Brioschi S, Colonna M. 2022 TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways. Cell, 185(22):4153-4169.e19. PMCID: PMC9625082

Chen Y, Colonna M. 2022 Spontaneous and induced adaptive immune responses in Alzheimer’s disease: new insights into old observations. Curr Opin Immunol, 77():102233. PMCID:

Gratuze M, Chen Y, Parhizkar S, Jain N, Strickland MR, Serrano JR, Colonna M, Ulrich JD, Holtzman DM. 2021 Activated microglia mitigate Aβ-associated tau seeding and spreading. J Exp Med, 218(8):e20210542. PMCID: PMC8190588

Chen Y, Colonna M. 2021 Microglia esprit de corps: Sharing the burden of eliminating toxic aggregates. Cell, 184(20):5082-84

Molgora M, Esaulova E, Vermi W, Hou J, Chen Y, Luo J, Brioschi S, Bugatti M, Omodei AS, Ricci B, Fronick C, Panda SK, Takeuchi Y, Gubin MM, Faccio R, Cella M, Gilfillan S, Unanue ER, Artyomov MN, Schreiber RD, Colonna M. 2020 TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy. Cell, S0092-8674(20):30878-3. PMCID:

Chen Y, Strickland MR, Soranno A, Holtzman DM. 2020 Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis. Neuron, ():S0896-6273(20)30776-5