• University of Colorado-Boulder (2016)

  • Molecular Microbiology and Microbial Pathogenesis

  • David Sibley, Ph.D.

  • The genetic and molecular characterization of the Cryptosporidium life cycle

  • abigail.kimball@wustl.edu

Research

My project is focused on the genetic and molecular characterization of the complex life cycle of Cryptosporidium parasites. I am utilizing scRNAseq and dimensionality reduction algorithms to examine transcriptional regulation throughout parasite development and pathogenesis. I am also generating tagged C. parvum via CRISPR/Cas9 in order to identify distinct life stages and examine centromere dynamics during cell division. The identification of robust genetic markers for C. parvum life stages will allow the field to utilize high throughput analysis methods. Furthermore, studying the complex process of sexual reproduction may reveal mechanisms for Cryptosporidium speciation and host adaptation.

Last Updated: 2/28/2020 10:47:12 AM

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