Faculty
Jeffrey Haspel, MD, PhD
Associate Professor
- Email: jhaspel@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease
Key words
Xueyan He, PhD
Assistant Professor
- Email: xueyanh@wustl.edu
Program affiliation
Cancer Biology
Immunology
Molecular Cell Biology
Research summary
Advancing knowledge of the mechanisms responsible for colorectal tumor progression, with a specific focus on Stress and its influence on the Tumor Microenvironment.
Key words
Tumor Microenvironment, Stress
Denise Head, PhD
Professor
- Email: dhead@wustl.edu
Program affiliation
Neurosciences
Research summary
Cognitive neuroscience of aging
Key words
aging, Alzheimer’s disease, cognition, imaging, structure-function relations
Andrew Heath, DPhil
Spencer T. Olin Professor of Psychology
- Email: aheath@wustl.edu
Program affiliation
Human and Statistical Genetics
Ecology and Evolutionary Biology
Biomedical Informatics and Data Science
Research summary
Genetic studies of alcoholism, smoking and drug dependence, depression, suicidality and anxiety disorders, personality disorders, and methodological research in genetic epidemiology
Key words
substance abuse, development, modeling, psychiatry, quantitative genetics
Jennifer Heemstra, PhD
Charles Allen Thomas Professor and Chair of the Department of Chemistry
- Email: heemstra@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Utilization of nucleic acid molecular recognition and self-assembly to generate functional architectures for biosensing and bioimaging
Key words
Chemical Biology, Molecular Recognition, Biomolecular Assembly, Nucleic Acids, Biosensors, Cellular Imaging, RNA Editing, Biomaterials
Lamees Hegazy, PhD
Associate Professor
- Email: lamees.hegazy@wustl.edu
Program affiliation
General
Research summary
My research centers on defining how the dynamic conformational landscape of drug targets governs ligand binding, selectivity, and downstream signaling. Using integrated approaches—including molecular dynamics simulations, pharmacophore modeling, and virtual screening—I identify and characterize novel modulators for several targts. These studies uncover previously unrecognized binding pockets, reveal mechanisms of ligand-induced activation or inhibition
Key words
Jason Held, PhD
Assistant Professor
- Email: jheld@wustl.edu
Program affiliation
Molecular Cell Biology
Cancer Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science
Research summary
Redox biochemistry in cell signaling and disease, Proteomics
Key words
proteomics, post-translational modification, cysteine, redox, mass spectrometry, oxidation
Jeffrey Henderson, MD, PhD
Professor
- Email: hendersonj@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Biochemical interactions between humans and bacteria in health and disease
Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics
Keith Hengen, PhD
Associate Professor
- Email: khengen@wustl.edu
Program affiliation
Neurosciences
Computational and Systems Biology
Molecular Cell Biology
Research summary
We take a "big data" approach to understanding the self-organization of neurons and networks in behaving animals.
Key words
Homeostatic plasticity, behavior, neurodegeneration, self-organization, emergence, learning, computational, computation, modeling