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Jeffrey Haspel, MD, PhD

Associate Professor

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease

Key words

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Xueyan He, PhD

Assistant Professor

Program affiliation
Cancer Biology
Immunology

Molecular Cell Biology

Research summary
Advancing knowledge of the mechanisms responsible for colorectal tumor progression, with a specific focus on Stress and its influence on the Tumor Microenvironment.

Key words
Tumor Microenvironment, Stress

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Denise Head, PhD

Professor

Program affiliation
Neurosciences

Research summary
Cognitive neuroscience of aging

Key words
aging, Alzheimer’s disease, cognition, imaging, structure-function relations

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Andrew Heath, DPhil

Spencer T. Olin Professor of Psychology

Program affiliation
Human and Statistical Genetics
Ecology and Evolutionary Biology
Biomedical Informatics and Data Science

Research summary
Genetic studies of alcoholism, smoking and drug dependence, depression, suicidality and anxiety disorders, personality disorders, and methodological research in genetic epidemiology

Key words
substance abuse, development, modeling, psychiatry, quantitative genetics

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Jennifer Heemstra, PhD

Charles Allen Thomas Professor and Chair of the Department of Chemistry

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
Utilization of nucleic acid molecular recognition and self-assembly to generate functional architectures for biosensing and bioimaging

Key words
Chemical Biology, Molecular Recognition, Biomolecular Assembly, Nucleic Acids, Biosensors, Cellular Imaging, RNA Editing, Biomaterials

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Lamees Hegazy, PhD

Associate Professor

Program affiliation
General

Research summary
My research centers on defining how the dynamic conformational landscape of drug targets governs ligand binding, selectivity, and downstream signaling. Using integrated approaches—including molecular dynamics simulations, pharmacophore modeling, and virtual screening—I identify and characterize novel modulators for several targts. These studies uncover previously unrecognized binding pockets, reveal mechanisms of ligand-induced activation or inhibition

Key words

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Jason Held, PhD

Assistant Professor

Program affiliation
Molecular Cell Biology
Cancer Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Redox biochemistry in cell signaling and disease, Proteomics

Key words
proteomics, post-translational modification, cysteine, redox, mass spectrometry, oxidation

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Jeffrey Henderson, MD, PhD

Professor

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Biochemical interactions between humans and bacteria in health and disease

Key words
bacterial pathogenesis, host-pathogen interactions, iron, mass spectrometry, medicinal chemistry, metabolomics

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Keith Hengen, PhD

Associate Professor

Program affiliation
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We take a "big data" approach to understanding the self-organization of neurons and networks in behaving animals.

Key words
Homeostatic plasticity, behavior, neurodegeneration, self-organization, emergence, learning, computational, computation, modeling

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Andreas Herrlich, MD, PhD

Associate Professor

Program affiliation
Molecular Cell Biology

Research summary
We aim to identify cellular and molecular mechanisms in the novel and rapidly expanding field of interorgan crosstalk in health and disease.

Key words