Biochemistry Biophysics and Structural Biology
Christopher Lingle, PhD
Professor
- Email: clingle@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Research summary
Structure-function studies of Slo family K+ channels
Key words
ion channel, protein structure, neurobiology, physiology, cell signaling
Timothy Lohman, PhD
Marvin A. Brennecke Professor of Biophysics
- Email: lohman@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Mechanisms of DNA helicases/translocases and SSB proteins
Key words
DNA recombination, DNA replication, fluorescence, molecular motors, single molecules, thermodynamics
Nupam Mahajan, PhD
Professor
- Email: nupam@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Cancer Biology
Research summary
How tyrosine phosphorylation regulates epigenetic processes that affect cellular homeostasis and cancer cell survival
Key words
Mohamed Mahjoub, PhD
Associate Professor
- Email: mmahjoub@wustl.edu
Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
The microtubule cytoskeleton in health and disease
Key words
Cell cytoskeleton, microtubules, cilia, centrosome, cell cycle, signal transduction, kidney/lung development and disease
Michael Major, PhD
Alan A. and Edith L. Wolff Professor
- Email: bmajor@wustl.edu
Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Computational and Systems Biology
Research summary
Studying how perturbation of specific signal transduction pathways contributes to the initiation, progression and dissemination of cancer
Key words
proteomics, functional genomics, lung cancer, signal transduction, WNT, oxidative stress
Susruta Majumdar, PhD
Professor (PEFA)
- Email: susrutam@wustl.edu
Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Research summary
Research in the laboratory is aimed at attaining functional selectivity of opioid agonist action from its own target adverse effects while integrating chemical synthesis with biochemical, genetic and pharmacological approaches.
Key words
opioids, GPCRs, biased signaling, pain, chemical biology
Jordan McCall, PhD
Assistant Professor
- Email: jordangmccall@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding the neural mechanisms underlying emotional dysregulation in the contexts of stress, chronic pain, and addiction
Key words
William McCoy, MD, PhD
Assistant Professor
- Email: mccoyw@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Biochemistry Biophysics and Structural Biology
Research summary
We investigate how host-microbe interactions at epithelial barrier sites impact skin diseases.
Key words
acne, microbiome, cryogenic electron microscopy, cryoEM, crystallography, Cutibacterium acnes, melanoma, immune checkpoint inhibitor, ICI
J. Mark Meacham, PhD
Associate Professor
- Email: meachamjm@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Studies microfluidics, micro-electromechanical systems and associated transport phenomena
Key words
Robert Mercer, PhD
Professor
- Email: rmercer@wustl.edu
Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Molecular and cell biology of ion pumps and transporters in plasma membrane; cell polarity
Key words
cell membrane, development, Na K-ATPase, excitable tissue, cell volume