Biochemistry Biophysics and Structural Biology

Program affiliation
Computational and Systems Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Systems and synthetic cell biology: quantitative analysis of cellular organization

Key words

Program affiliation
Molecular Cell Biology
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
Ion channel biology in health and disease

Key words
ion channel, neurobiology, functional genomics, cell signaling, kinetics

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Understanding how mitochondria are built, regulated, and maintained

Key words
mitochondria, phosphorylation, metabolism, signaling, kinase, phosphatase

Program affiliation
Plant and Microbial Biosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Circadian clock regulation of physiology and development in plants.

Key words
Plant Biology, circadian rhythms, biochemistry, genetics, Arabidopsis, mass spectrometry, chronobiology

Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology

Research summary
Okuno Lab investigates how water molecules interact with protein surfaces and explores the underlying mechanisms of protein folding and aggregation through NMR spectroscopy.

Key words
Biophysics, NMR, solvent, protein hydration, aggregation, reverse micelles

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.

Key words
Mitochondria, Protein biochemistry, Genetic screening, Metabolism, Biosynthesis, Orphan protein function, Proteomics, Metabolomics, Kinases and phosphates, Metabolic disease, Systems biochemistry

Program affiliation
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
Systems and Synthetic Biology of photosynthetic organisms

Key words
Bioenergy, membrane proteins, photosynthesis, redox processes, systems biology, synthetic biology

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Immunology

Research summary
https://sites.wustl.edu/panlab/

Key words
Onco-Nephrology, Cardio-Oncology, Cancer, MRI, Gene/drug delivery, Machine Learning

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
Biophysics of intrinsically disordered proteins

Key words
Huntington`s disease; Polyglutamine Aggregation; Intrinsically Disordered Proteins; Phase transitions in cell biology; Self-assembly; Transcriptional regulation; Small-scale Systems Biology & Interaction Networks;

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
We combine experimental measurements and computational modeling to understand how single and grouped respond to physical heterogeneities present in their extracellular microenvironments.

Key words
Mechanobiology; tumor invasion; cell migration; epithelial-mesenchymal transition; cell-matrix interaction; cytoskeleton;