Biochemistry Biophysics and Structural Biology
Michael Major, PhD
Alan A. and Edith L. Wolff Professor
- Email: bmajor@wustl.edu
Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Computational and Systems Biology
Research summary
Studying how perturbation of specific signal transduction pathways contributes to the initiation, progression and dissemination of cancer
Key words
proteomics, functional genomics, lung cancer, signal transduction, WNT, oxidative stress
Susruta Majumdar, PhD
Professor (PEFA)
- Email: susrutam@wustl.edu
Program affiliation
Neurosciences
Biochemistry Biophysics and Structural Biology
Research summary
Research in the laboratory is aimed at attaining functional selectivity of opioid agonist action from its own target adverse effects while integrating chemical synthesis with biochemical, genetic and pharmacological approaches.
Key words
opioids, GPCRs, biased signaling, pain, chemical biology
Jordan McCall, PhD
Associate Professor
- Email: jordangmccall@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding the neural mechanisms underlying emotional dysregulation in the contexts of stress, chronic pain, and addiction
Key words
William McCoy, MD, PhD
Assistant Professor
- Email: mccoyw@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Biochemistry Biophysics and Structural Biology
Research summary
We investigate how host-microbe interactions at epithelial barrier sites impact skin diseases.
Key words
acne, microbiome, cryogenic electron microscopy, cryoEM, crystallography, Cutibacterium acnes, melanoma, immune checkpoint inhibitor, ICI
J. Mark Meacham, PhD
Associate Professor
- Email: meachamjm@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Studies microfluidics, micro-electromechanical systems and associated transport phenomena
Key words
Timothy Miller, MD, PhD
David Clayson Professor
- Email: miller.t@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Mechanisms of neurodegeneration and targeted therapies for neurodegenerative diseases
Key words
ALS (amyotrophic lateral sclerosis), SOD1, TDP-43, C9ORF72, miRNA, Tau, Dementia, Neurodegeneration, Antisense oligonucleotides
Makedonka Mitreva, PhD
Professor
- Email: mmitreva@wustl.edu
Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Research summary
Next-generation experimental, multi-omic and computational approaches to empower the study of infectious diseases and the human microbiome
Key words
Genomics of Infectious Diseases, Helminth Genomics, Human Metagenomics
Kevin Moeller, PhD
Professor
- Email: moeller@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Developing new methods for peptide mimetic, natural product synthesis, and the construction of addressable molecular arrays
Key words
biosensors, electrochemistry, medicinal chemistry, organic synthesis, reactive intermediates
Jose Moron-Concepcion, PhD
Professor
- Email: jmoron-concepcion@wustl.edu
Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Elucidating the molecular mechanisms underlying opiate dependence
Key words
opioids, addiction, pain, molecular mechanisms, animal models
Nima Mosammaparast, MD, PhD
Associate Professor
- Email: nima@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding how RNA modifications influence transcription, signaling, and genomic integrity
Key words
RNA modifications, cancer , transcription, DNA repair