Biochemistry Biophysics and Structural Biology
David Piston, PhD
Edward Mallinckrodt, Jr. Professor and Head of the Department of Cell Biology & Physiology
- Email: piston@wustl.edu
Program affiliation
Molecular Cell Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science
Research summary
Studies of the Molecular Pathways of Islet Hormone Secretion
Key words
Diabetes, Biophysics, Systems Biology, Computational Biology, Hyperspectral Imaging, Glucagon
Jay Ponder, PhD
Associate Professor
- Email: ponder@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Research summary
Computational chemistry, protein engineering, theoretical protein structure and folding
Key words
molecular modeling, protein structure, computational chemistry, molecular dynamics simulation, protein engineering
Sumanth Prabhu, MD
Tobias & Hortense Lewin Distinguished Professor of Cardiovascular Disease
- Email: prabhu@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Cell Biology
Research summary
Key words
Courtney Reichhardt, PhD
Assistant Professor
- Email: creichhardt@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Research summary
Investigating the fundamental biophysical principles of biofilm assembly
Key words
Janice Robertson, PhD
Associate Professor
- Email: janice.robertson@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Neurosciences
Research summary
To understand how and why membrane proteins fold, form stable complexes, and achieve conformational stability inside of the oil-filled cell membrane.
Key words
membrane protein; single-molecule; TIRF microscopy; protein folding; thermodynamics; lipids; oligomerization
Ronald Rubenstein, MD, PhD
Robert C. Strunk Endowed Chair for Lung and Respiratory Research Professor
- Email: rubenstein@wustl.edu
Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding the mechanisms by which a novel chaperone of the Endoplasmic Reticulum, ERp29, regulates the biogenesis of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Epithelial Sodium Channel (ENaC), and other proteins related to pediatric pulmonary diseases
Key words
Cystic Fibrosis, Chaperone, Endoplasmic Reticulum, CFTR, ENaC/Epithelial Sodium Channel, Epithelia, Insulin, Trafficking, Biogenesis
Deborah Rubin, MD
Professor
- Email: drubin@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Intestinal stem cells and the stem cell niche in intestinal injury/short bowel syndrome and colitis associated colon cancer, early colon cancer pathogenesis
Key words
Stem cells, epithelial proliferation, cancer, short bowel syndrome
Yoram Rudy, PhD, FAHA, FHRS
The Fred Saigh Distinguished Professor of Engineering
- Email: rudy@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Multiscale studies of cardiac electrophysiology and arrhythmia using computational biology and imaging
Key words
ion channels, protein dynamics, cardiac cell electrophysiology, cardiac imaging
Rajan Sah, MD, PhD
Associate Professor
- Email: rajan.sah@wustl.edu
Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Study the function of novel ion channels as they relate to growth and metabolism
Key words
Marco Sardiello, PhD
Associate Professor
- Email: sardiello@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Research summary
My laboratory uses genetics, cell biology and systems biology approaches to study how the cell regulates its metabolic programs and how dysfunctions in these programs lead to neurological disease
Key words