Biochemistry Biophysics and Structural Biology
Ronald Rubenstein, MD, PhD
Robert C. Strunk Endowed Chair for Lung and Respiratory Research Professor
- Email: rubenstein@wustl.edu
Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding the mechanisms by which a novel chaperone of the Endoplasmic Reticulum, ERp29, regulates the biogenesis of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the Epithelial Sodium Channel (ENaC), and other proteins related to pediatric pulmonary diseases
Key words
Cystic Fibrosis, Chaperone, Endoplasmic Reticulum, CFTR, ENaC/Epithelial Sodium Channel, Epithelia, Insulin, Trafficking, Biogenesis
Rajan Sah, MD, PhD
Associate Professor
- Email: rajan.sah@wustl.edu
Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
Study the function of novel ion channels as they relate to growth and metabolism
Key words
Marco Sardiello, PhD
Associate Professor
- Email: sardiello@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Research summary
My laboratory uses genetics, cell biology and systems biology approaches to study how the cell regulates its metabolic programs and how dysfunctions in these programs lead to neurological disease
Key words
Clay Semenkovich, MD
Irene E. and Michael M. Karl Professor
- Email: csemenko@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Research summary
Molecular and cell biology of atherosclerosis and diabetes
Key words
aging, atherosclerosis, diabetes, lipids, obesity
Jieya Shao, PhD
Associate Professor
- Email: shao.j@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Research summary
Molecular mechanisms and therapeutic potential of novel cancer targets
Key words
cancer, genome stability, targeted therapy, proteostasis, autophagy, DNA replication stress, DNA damage response, phosphorylation
Jin-Yu Shao, PhD
Associate Professor and Associate Chairman
- Email: shao@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Cellular and molecular engineering
Key words
blood coagulation, cell/tissue mechanics, inflammation, modeling, molecular biomechanics, protein-protein interaction
Vijay Sharma, PhD
Associate Professor
- Email: sharmav@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Research summary
Design and Development of Small Organics and Metalloprobes for Radiological Molecular Imaging in Biomedical Science
Key words
Molecular Imaging, PET and SPECT Agents, Myocardial Perfusion, Alzheimer`s Disease, Multidrug Resistance
Chen Shen, PhD
Assistant Professor
- Email: shenc@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Understand the structural mechanisms of host-pathogen interactions and the inflammasome signaling
Key words
structural biology, innate immunity, pattern recognition receptors, immune recognition, inflammasomes
Leonid Shmuylovich, MD,PhD
Assistant Professor
- Email: shmuylol@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science
Research summary
Develop optical imaging technologies that address clinical problems with a focus on dermatology
Key words
dermatology imaging engineering pigmentation global heath
Monica Shokeen, PhD
Associate Professor
- Email: shokeenm@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Immunology
Research summary
Development and evaluation of small- and macro-molecular agents for multi-modal molecular imaging of cancer and cardiovascular diseases
Key words