Biochemistry Biophysics and Structural Biology
Clay Semenkovich, MD
Irene E. and Michael M. Karl Professor
- Email: csemenko@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Research summary
Molecular and cell biology of atherosclerosis and diabetes
Key words
aging, atherosclerosis, diabetes, lipids, obesity
Jieya Shao, PhD
Associate Professor
- Email: shao.j@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Research summary
Molecular mechanisms and therapeutic potential of novel cancer targets
Key words
cancer, genome stability, targeted therapy, proteostasis, autophagy, DNA replication stress, DNA damage response, phosphorylation
Vijay Sharma, PhD
Associate Professor
- Email: sharmav@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Research summary
Design and Development of Small Organics and Metalloprobes for Radiological Molecular Imaging in Biomedical Science
Key words
Molecular Imaging, PET and SPECT Agents, Myocardial Perfusion, Alzheimer`s Disease, Multidrug Resistance
Chen Shen, PhD
Assistant Professor
- Email: shenc@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis
Research summary
Understand the structural mechanisms of host-pathogen interactions and the inflammasome signaling
Key words
structural biology, innate immunity, pattern recognition receptors, immune recognition, inflammasomes
Monica Shokeen, PhD
Associate Professor
- Email: shokeenm@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Immunology
Research summary
Development and evaluation of small- and macro-molecular agents for multi-modal molecular imaging of cancer and cardiovascular diseases
Key words
Srikanth Singamaneni, PhD
Associate Professor
- Email: singamaneni@WUSTL.EDU
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Plasmonic biosensors and biomimetic sensors
Key words
biomimetic sensors, plasmonic biosensors, nanostructures, transduction platforms
Nathan Singh, MD, MS
Associate Professor
- Email: nathan.singh@wustl.edu
Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding how synthetic antigen receptors direct T cell function and dysfunction in the treatment of blood cancers
Key words
CAR T cell therapy, immunotherapy for cancer, T cell signaling, T cell dysfunction, lineage decisions
Andrea Soranno, PhD
Associate Professor
- Email: soranno@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Research summary
Role of disordered proteins in function and dysfunction: from Alzheimer's disease to SARS CoV 2
Key words
disordered proteins, single molecule, fluorescence, FRET, Alzheimer's disease, SARS CoV 2 nucleocapsid, Apolipoprotein E, ApoE, biomolecular condensates, polymer models
Christina Stallings, PhD
Professor
- Email: stallings@wustl.edu
Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Research summary
Molecular pathogenesis of Mycobacterium tuberculosis
Key words
bacteria, gene regulation, molecular genetics, microbiology, pathogenesis, transcription, infectious disease, innate immunity
Sheila Stewart, PhD
Professor
- Email: sheila.stewart@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Research summary
Examining the role the tumor microenvironment plays in immune modulation, tumor development, metastasis and dormancy
Key words
aging, cancer, microenvironment, RNAi, senescence, telomere