Biochemistry Biophysics and Structural Biology
Rohit Pappu, PhD
Gene K Beare Distinguished Professor
- Email: pappu@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Plant and Microbial Biosciences
Research summary
Biophysics of intrinsically disordered proteins
Key words
Huntington`s disease; Polyglutamine Aggregation; Intrinsically Disordered Proteins; Phase transitions in cell biology; Self-assembly; Transcriptional regulation; Small-scale Systems Biology & Interaction Networks;
Amit Pathak, PhD
Associate Professor
- Email: pathaka@wustl.edu
Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Research summary
We combine experimental measurements and computational modeling to understand how single and grouped respond to physical heterogeneities present in their extracellular microenvironments.
Key words
Mechanobiology; tumor invasion; cell migration; epithelial-mesenchymal transition; cell-matrix interaction; cytoskeleton;
Gary Patti, PhD
Michael and Tana Powell Professor
- Email: gjpattij@wustl.edu
Program affiliation
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science
Research summary
To understand the metabolic crosstalk between cells and tissues in disease models such as cancer by using isotopes and metabolomics
Key words
metabolism, metabolomics, mass spectrometry, bioinformatics, imaging, cancer, tumor microenvironment, isotope tracing
Philip Payne, PhD, FACMI
Janet and Bernard Becker Professor
- Email: prpayne@wustl.edu
Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Research summary
Translational Bioinformatics, Clinical Research Informatics
Key words
Biomedical Informatics, Data Science, Data Analytics, Clinical Research, Translational Research
Linda Pike, PhD
Professor
- Email: pike@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Research summary
EGF receptor-mediated cell signaling and the control of cell growth
Key words
signal transduction, cell signaling, cancer, EGF receptor
David Piston, PhD
Edward Mallinckrodt, Jr. Professor and Head of the Department of Cell Biology & Physiology
- Email: piston@wustl.edu
Program affiliation
Molecular Cell Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science
Research summary
Studies of the Molecular Pathways of Islet Hormone Secretion
Key words
Diabetes, Biophysics, Systems Biology, Computational Biology, Hyperspectral Imaging, Glucagon
Jay Ponder, PhD
Associate Professor
- Email: ponder@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Research summary
Computational chemistry, protein engineering, theoretical protein structure and folding
Key words
molecular modeling, protein structure, computational chemistry, molecular dynamics simulation, protein engineering
Sumanth Prabhu, MD
Tobias & Hortense Lewin Distinguished Professor of Cardiovascular Disease
- Email: prabhu@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Cell Biology
Research summary
Key words
Courtney Reichhardt, PhD
Assistant Professor
- Email: creichhardt@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences
Research summary
Investigating the fundamental biophysical principles of biofilm assembly
Key words
Janice Robertson, PhD
Associate Professor
- Email: janice.robertson@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Neurosciences
Research summary
To understand how and why membrane proteins fold, form stable complexes, and achieve conformational stability inside of the oil-filled cell membrane.
Key words
membrane protein; single-molecule; TIRF microscopy; protein folding; thermodynamics; lipids; oligomerization