Biochemistry Biophysics and Structural Biology

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology
Biomedical Informatics and Data Science
Biochemistry Biophysics and Structural Biology

Research summary
My lab seeks to understand how DNA sequence determines its regulatory function. We combine functional genomic technologies with deep learning models to answer this question.

Key words
computational biology, gene regulation, genomics, deep learning, technology development

Program affiliation
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Role of transcription factors in differentiation and development

Key words
embryonic development, lung development, mouse models, transcriptional regulation

Program affiliation
Biochemistry Biophysics and Structural Biology
Neurosciences
Molecular Cell Biology
Cancer Biology

Research summary
Alzheimer’s disease, Parkinson's disease, central nervous disorders, postmortem biomarker validation and characterization, in vivo positron emission tomography, in vitro quantitative autoradiography

Key words
Imaging, biomarkers, cancer, neuroscience, PET, quantitative autoradiography, pharmaceuticals, biological assays, human brain function and disease

Program affiliation
Biochemistry Biophysics and Structural Biology

Research summary
We develop various light-wave based technologies, such as novel sensors, spectroscopy and imaging systems, for biological and medical applications.

Key words
nanotechnology, photonics, material physics, biosensing, spectroscopy, imaging

Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding the mechanisms of nervous system construction and dysfunction.

Key words

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Biochemistry Biophysics and Structural Biology

Research summary

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Plant and Microbial Biosciences
Molecular Cell Biology

Research summary
Mechanism of translational fidelity and its impact on cellular fitness and codon evolution

Key words
Translation, Ribosome, RNA, Fidelity, peptide-bond formation, pre-steady state kinetics, translational regulation

Program affiliation
Molecular Cell Biology
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
The mechanisms that influence arterial collateral formation and peripheral arterial atheroprogression in the setting of diabetes

Key words

Program affiliation
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Synthetic biology for advanced biofuels, biomaterials, and chemicals.

Key words
Synthetic biology, Metabolic engineering, regulatory systems, biomaterials

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Cryo-EM study of native macromolecular complexes related to microtubule and cilia

Key words