Cancer Biology
Joshua Rubin, MD, PhD
Professor
- Email: Rubin_J@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Neurosciences
Research summary
Molecular mechanisms in pediatric brain tumorigenesis
Key words
tumor biology, signal transduction, stem cells, neural development, sexual dimorphism, circadaian rhythm, chemokines, cAMP
Robert Schreiber, PhD
Alumni Endowed Professor
- Email: rdschreiber@wustl.edu
Program affiliation
Immunology
Cancer Biology
Research summary
Cytokine receptor signaling and immunological protection against tumor development
Key words
cancer, lymphocyte, cytokine, signal transduction, tumor editing
Julie Schwarz, MD, PhD
Professor and Vice Chair of Research
- Email: jschwarz@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Research summary
Studying cancer therapy resistance mechanisms in humans and preclinical models
Key words
Tumor metabolism, glycolysis, glutaminolysis, imaging, microenvironment, HPV, immunology, radiation therapy
Jieya Shao, PhD
Associate Professor
- Email: shao.j@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Research summary
Molecular mechanisms and therapeutic potential of novel cancer targets
Key words
cancer, genome stability, targeted therapy, proteostasis, autophagy, DNA replication stress, DNA damage response, phosphorylation
Monica Shokeen, PhD
Associate Professor
- Email: shokeenm@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Immunology
Research summary
Development and evaluation of small- and macro-molecular agents for multi-modal molecular imaging of cancer and cardiovascular diseases
Key words
Jessica Silva-Fisher, PhD
Assistant Professor
- Email: silvajm@wustl.edu
Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Research summary
Long non-coding RNAs and RNA modifications in cancer metastasis and relapse
Key words
Cancer metastasis, multiple myeloma, breast cancer, long non-coding RNAs, RNA modifications, genomics
Nathan Singh, MD, MS
Assistant Professor
- Email: nathan.singh@wustl.edu
Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding how synthetic antigen receptors direct T cell function and dysfunction in the treatment of blood cancers
Key words
CAR T cell therapy, immunotherapy for cancer, T cell signaling, T cell dysfunction, lineage decisions
George Souroullas, PhD
Assistant Professor
- Email: george.souroullas@wustl.edu
Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Understand how epigenetic mechanisms and chromatin dynamics contribute towards the development of cancer.
Key words
Epigenetics, chromatin, cancer, mouse models, lymphoma, melanoma, EZH2, PRC2, H3K27me3
David Spencer, MD, PhD
Associate Professor
- Email: dspencer@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology
Research summary
My research program studies epigenetic gene regulation in cancer, with a specific emphasis on understanding how mutations in acute myeloid leukemia (AML) perturb the epigenome to alter gene expression and cause leukemia.
Key words
Alexander Stegh, PhD
Professor
- Email: stegh@wustl.edu
Program affiliation
Cancer Biology
Research summary
Glioblastoma metabolism, mechanisms of immunosupression, and the development of novel gene-regulatory and immunostimulatory nanotechnologies
Key words