Cancer Biology

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Examining the role the tumor microenvironment plays in immune modulation, tumor development, metastasis and dormancy

Key words
aging, cancer, microenvironment, RNAi, senescence, telomere

Program affiliation
Cancer Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Identify and define those molecular features that drive leukemogenesis and then use that information to develop rational therapeutic strategies for improving outcomes in acute leukemia

Key words

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Immunology
Molecular Cell Biology
Neurosciences

Research summary
Cancer-Stroma interactions in metastasis

Key words
cancer metastasis; tumor microenvironment, cancer immunology, CRISPR screen, quantitative biology

Program affiliation
Cancer Biology

Research summary
We develop and evaluate theranostic agents, dual modality diagnostic and therapeutic agents for disease applications. We considers questions of drug development, disease characterization and biological responses with a focus on near term translational relevance.

Key words
cancer, therapy, radiology, radiation oncology, theranostics

Program affiliation
Cancer Biology
Human and Statistical Genetics
Immunology
Molecular Genetics and Genomics

Research summary
Associations of metabolic imbalance, inflamation with cancer etiology and survival

Key words
Biomarkers, inflammation, metabolic imbalance, mammographic density, breast cancer, colorectal cancer, prevention,

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Immunology
Cancer Biology

Research summary
We want to understand how microbes interact with humans so that we can identify new strategies to improve health. Our research integrates 'skinomics', metagenomics and host-microbial genetics to address how microbes influence skin physiology.

Key words
microbiome, skin, dermatology, skin diseases, infection, skin cancer, wound healing, environmental exposures

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding the metabolism of sarcomas for therapeutic development

Key words
Cancer, Metabolism, Human in mouse Cancer Models, New Therapies, Tumor Models, Metobolomics, Mouse Genetics

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Immunology
Cancer Biology

Research summary
The bone microenvironment for cancer and infection

Key words
bone biology, osteoclast, cancer, metastasis, osteoporosis, microenvironment, osteoblast, osteomyelitis, infection

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
Understanding DNA repair mechanisms that impact cancer etiology and responses to chemotherapies

Key words
DNA repair and replication; Genomic instability in cancers; Oncogenes; BRCA-mutation

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
DNA replication and repair, and the roles of these pathways on cancer initiation, progression and response to chemotherapy and immunotherapy

Key words
genome stability, DNA repair, DNA replication, chemotherapy response, cancer etiology