Cancer Biology

Program affiliation
Immunology
Cancer Biology

Research summary
Circulating tumor cell biology, use of AI on digital histologic images to predict prognosis and response to therapy

Key words
Artificial Intelligence, Machine Learning, Digital Pathology, Circulating Tumor Cells, Response to Therapy,

Program affiliation
Neurosciences
Cancer Biology
Immunology

Research summary
The primary research goal of our laboratory is to uncover novel ways to alter the pediatric brain tumor microenvironment to enhance the efficacy of existing treatments and make treatments safer for children.

Key words
brain tumors, cancer, neurology, immunology, imaging

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
My lab is interested in understanding how dysregulation of the Core Binding Factor transcription factor promotes AML development

Key words
hematopoiesis, leukemia, AML, acute myeloid leukemia, CBF, RUNX1, CBFB, core binding factor

Program affiliation
Cancer Biology
Molecular Cell Biology
Immunology

Research summary
Molecular Mechanisms of Immune Regulation of Tumor Progression.

Key words
immunotherapy, breast cancer, pancreatic cancer, immunology, inflammation, metastasis, storm

Program affiliation
Immunology
Cancer Biology
Molecular Cell Biology

Research summary
The DeSelm Lab focuses on engineering immune cells with chimeric antigen receptors (CARs) to better understand tumor-immune interactions and develop next generation therapies for cancer, Alzheimer's Disease, and other incurable conditions.

Key words
Immunotherapy, cancer, CAR T-cells, CAR-DC1

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Cancer Proteogenomics and Cancer Models

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Cancer Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Cells are not just bags of molecules - they organize their biochemistry in space, often using dynamic compartments called biomolecular condensates. Our lab is asking fundamental questions about the role of condensates in biology, such as: how do condensate environments influence RNA recognition and metabolism? How do they alter the activity of therapeutics? And how do they contribute to oncogenic cell states? We do this using interdisciplinary approaches spanning chemical biology, quantitative cell microscopy, in vitro biophysics, and machine learning. We hope to ultimately uncover how subcellular organization shapes cellular function and how these principles can be harnessed therapeutically.

Key words
condensates, RNA, chemical biology, therapeutics, microscopy, cancer

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Cancer Biology

Research summary
Identifying preventive strategies to reduce cancer disparities

Key words

Program affiliation
Molecular Cell Biology
Immunology
Cancer Biology

Research summary
interactions between bone and immune cells in inflammation and cancer

Key words
arthritis, inflammation, cancer, bone metastases, osteoclasts

Program affiliation
Immunology
Cancer Biology

Research summary
My laboratory is focused on the molecular mechanisms regulating natural killer cell activation, novel methods to use NK cells as immunotherapy for cancer, and lymphoma genomics.

Key words
cancer, cytokine, immunology, innate immunity, NK cells, small noncoding RNAs, immunotherapy, lymphoma, genomics