Cancer Biology

Program affiliation
Cancer Biology
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics

Research summary
We use both mouse models and patient samples of acute myloid leukemia to understand leukemogenesis and to identify novel therapeutic targets.

Key words

Program affiliation
Computational and Systems Biology
Immunology
Cancer Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
My research interests lie in integrating and applying novel computational biology techniques with mechanistic experimental immunology to understand drivers of response and resistance to NK cell therapies for cancer

Key words
natural killer cells, computational biology, single-cell sequencing, immunotherapy, nk cells

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Neurosciences
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
Small molecule drug discovery inspired research across multiple therapeutic areas including chronic pain, oncology, and neurodegeneration.

Key words
drug discovery, medicinal chemistry, chemical biology, synthetic methods

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology

Research summary
Translational research in the intersection of computational breast imaging, artificial intelligence, and informatics towards improving breast cancer screening

Key words
breast cancer, computational imaging analytics, machine learning, deep learning, artificial intelligence, big data, data science, precision medicine

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology
Computational and Systems Biology

Research summary
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.

Key words
AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Cancer Biology

Research summary
We study host-microbe and microbe-microbe interactions in the female reproductive and urinary tracts, with a focus on the vaginal microbiome, UTI, and adverse pregnancy outcomess

Key words
bacteria, bacterial pathogenesis, urinary tract infection, vaginal microbiome, women's health, host-pathogen interactions, mucosal immunology, epithelium

Program affiliation
Immunology
Cancer Biology

Research summary
Development of a breast cancer vaccine

Key words
antigen presentation, breast cancer, translational research, T cells, vaccine

Program affiliation
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology

Research summary

Key words

Program affiliation
Molecular Cell Biology
Cancer Biology
Molecular Genetics and Genomics

Research summary
Metabolism of cancer, targeting tumor metabolism by blocking metabolic pathways

Key words

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Our lab works on endogenous etiologies of mutagenesis and genome instability in pediatric cancers

Key words
leukemia, pediatric cancer, DNA damage, DNA replication, hematopoiesis