Cancer Biology

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology

Research summary
Translational research in the intersection of computational breast imaging, artificial intelligence, and informatics towards improving breast cancer screening

Key words
breast cancer, computational imaging analytics, machine learning, deep learning, artificial intelligence, big data, data science, precision medicine

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology
Computational and Systems Biology

Research summary
Our research focuses on unraveling the molecular mechanisms underlying substrate specificity and degradation by AAA proteolytic machines and their associated adaptor proteins, utilizing structural biology, biochemistry, and cellular assays in both bacteria and human mitochondria.

Key words
AAA proteases, cryo-EM, biochemistry, mass spectrometry, structural biology, microbiology, mitochondria

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Cancer Biology

Research summary
We study host-microbe and microbe-microbe interactions in the female reproductive and urinary tracts, with a focus on the vaginal microbiome, UTI, and adverse pregnancy outcomess

Key words
bacteria, bacterial pathogenesis, urinary tract infection, vaginal microbiome, women's health, host-pathogen interactions, mucosal immunology, epithelium

Program affiliation
Immunology
Cancer Biology

Research summary
Development of a breast cancer vaccine

Key words
antigen presentation, breast cancer, translational research, T cells, vaccine

Program affiliation
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology

Research summary

Key words

Program affiliation
Molecular Cell Biology
Cancer Biology
Molecular Genetics and Genomics

Research summary
Metabolism of cancer, targeting tumor metabolism by blocking metabolic pathways

Key words

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Our lab works on endogenous etiologies of mutagenesis and genome instability in pediatric cancers

Key words
leukemia, pediatric cancer, DNA damage, DNA replication, hematopoiesis

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
Deciphering the molecular mechanisms of epigenetics and how when this goes awry diseases arise

Key words
Epigenetics, Transgenerational, Imprinting, Evolution, Multicellularity, Cancer, Tumorigenesis, Epitranscriptomics

Program affiliation
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Cancer Biology
Computational and Systems Biology

Research summary
Improving our understanding of human disease biology and the development of personalized medicine strategies using genomics and informatics technologies

Key words
genomics, bioinformatics, data mining, immunogenomics, precision medicine, personalized medicine, cancer vaccines, and cancer research

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology
Molecular Cell Biology
Immunology

Research summary
Development of personalized medicine strategies for cancer using genomic technologies

Key words
bioinformatics, machine learning, cancer, genomics, immunogenomics, precision oncology