Cancer Biology

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
Deciphering the molecular mechanisms of epigenetics and how when this goes awry diseases arise

Key words
Epigenetics, Transgenerational, Imprinting, Evolution, Multicellularity, Cancer, Tumorigenesis, Epitranscriptomics

Program affiliation
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Cancer Biology
Computational and Systems Biology

Research summary
Improving our understanding of human disease biology and the development of personalized medicine strategies using genomics and informatics technologies

Key words
genomics, bioinformatics, data mining, immunogenomics, precision medicine, personalized medicine, cancer vaccines, and cancer research

Program affiliation
Biomedical Informatics and Data Science
Cancer Biology
Molecular Cell Biology
Immunology

Research summary
Development of personalized medicine strategies for cancer using genomic and bioinformatic technologies

Key words
Bioinformatics, Machine Learning, Cancer, Genomics, Immunogenomics, Precision Oncology, AI

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding tumor-microenvironment interactions and metastasis with a focus in ovarian cancer models

Key words
tumor microenvironment, microfluidics, metastasis, cancer, signal transduction

Program affiliation
Neurosciences
Cancer Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology

Research summary
The Gutmann laboratory is dedicated to understanding why brain tumors develop in children and young adults. Specifically, we focus on neurofibromatosis type 1 (NF1), a genetic condition in which affected children and adults develop brain tumors, attention deficit, and autism.

Key words
neurogenetics, , hiPSC engineering (organoids), genetically engineered mice, pediatric brain cancer, cancer immunology, cancer neuroscience

Program affiliation
Cancer Biology
Molecular Cell Biology

Research summary
The mechanisms of cell death in normal tissues during cancer therapy

Key words
cancer, cell death, drug delivery, radiation, signal transduction

Program affiliation
Cancer Biology
Immunology
Molecular Cell Biology

Research summary
Advancing knowledge of the mechanisms responsible for colorectal tumor progression, with a specific focus on Stress and its influence on the Tumor Microenvironment.

Key words
Tumor Microenvironment, Stress

Program affiliation
Cancer Biology
Immunology

Research summary
The Herzog Lab at Washington University School of Medicine focuses on understanding the tumor microenvironment (TME) in thoracic malignancies, with a particular emphasis on lung cancer. We combine cutting-edge immunology, genomics, and translational approaches to identify mechanisms of immune evasion and develop novel combination immunotherapy strategies.

Key words
CAFs, Cancer-associated fibroblasts, lung cancer, NSCLC, immunotherapy, cancer immunity

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Utilization of genomic information from sarcomas to better understand the pathogenesis of these tumors and to identify biomarkers and therapeutic targets for these aggressive cancers.

Key words
sarcoma, metastasis, genomics, cell signalling, NF1, MPNST

Program affiliation
Cancer Biology
Immunology

Research summary
Understanding T cell tolerance to self and non-self

Key words
autoimmunity, immunology, lymphocyte, regulatory T cell, tolerance, mucosal immunology