Cancer Biology
Whitney Grither, MD,PhD
Assistant Professor
- Email: gritherw@wustl.edu
Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Research summary
Understanding tumor-microenvironment interactions and metastasis with a focus in ovarian cancer models
Key words
tumor microenvironment, microfluidics, metastasis, cancer, signal transduction
David H. Gutmann, MD, PhD
Donald O. Schnuck Family Professor
- Email: gutmannd@wustl.edu
Program affiliation
Neurosciences
Cancer Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Research summary
The Gutmann laboratory is dedicated to understanding why brain tumors develop in children and young adults. Specifically, we focus on neurofibromatosis type 1 (NF1), a genetic condition in which affected children and adults develop brain tumors, attention deficit, and autism.
Key words
neurogenetics, , hiPSC engineering (organoids), genetically engineered mice, pediatric brain cancer, cancer immunology, cancer neuroscience
Dennis E. Hallahan, MD
Professor and Head of the Department of Radiation Oncology
- Email: dhallahan@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Research summary
The mechanisms of cell death in normal tissues during cancer therapy
Key words
cancer, cell death, drug delivery, radiation, signal transduction
Xueyan He, PhD
Assistant Professor
- Email: xueyanh@wustl.edu
Program affiliation
Cancer Biology
Immunology
Molecular Cell Biology
Research summary
Advancing knowledge of the mechanisms responsible for colorectal tumor progression, with a specific focus on Stress and its influence on the Tumor Microenvironment.
Key words
Tumor Microenvironment, Stress
Brett Herzog, MD,PhD
Assistant Professor
- Email: bherzog@wustl.edu
Program affiliation
Cancer Biology
Immunology
Research summary
Key words
Angela Hirbe, MD, PhD
Associate Professor
- Email: hirbea@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Utilization of genomic information from sarcomas to better understand the pathogenesis of these tumors and to identify biomarkers and therapeutic targets for these aggressive cancers.
Key words
sarcoma, metastasis, genomics, cell signalling, NF1, MPNST
Chyi-Song Hsieh, MD, PhD
Professor
- Email: chsieh@wustl.edu
Program affiliation
Cancer Biology
Immunology
Research summary
Understanding T cell tolerance to self and non-self
Key words
autoimmunity, immunology, lymphocyte, regulatory T cell, tolerance, mucosal immunology
Joseph Ippolito, MD, PhD
Associate Professor
- Email: ippolitoj@wustl.edu
Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Neurosciences
Research summary
Precision medicine through metabolism-based imaging and therapy: from laboratory to clinical translation
Key words
cancer, metabolism, imaging, sex differences, body composition
James W. Janetka, PhD
Professor
- Email: janetkaj@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Research summary
The rational structure-based drug design and synthesis for cancer and infectious disease
Key words
protease, kinase, cancer, infection, lectin, chemistry, synthesis, drug discovery, peptidomimetic, inhibitor
Shu (Joy) Jiang, PhD
Assistant Professor
- Email: jiang.shu@wustl.edu
Program affiliation
Biomedical Informatics and Data Science
Cancer Biology
Research summary
Development of novel statistical methods for precision medicine
Key words
Biostatistics; Image analysis; Dynamic risk prediction; Multistate models