Cancer Biology

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Cancer Biology

Research summary
I am interested in precursor conditions or metaplasias in the stomach and esophagus (i.e Barrett’s esophagus) as these lesions are key to understanding the formation of gastroesophageal adenocarcinomas.

Key words
Intestinal metaplasia, gastroesophageal cancer, Barrett's esophagus, GI development, Organoids

Program affiliation
Immunology
Cancer Biology

Research summary
Novel immunotherapeutic strategies to treat solid tumors

Key words

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Immunology

Research summary
Decoding cell fate decision mechanisms to modulate lineage output for therapeutic purpose

Key words
Hematopoietic stem cells, Multipotent progenitors, Cell fate decision, Lineage specification, Stem cell biology, Cancer (myeloid leukemia), Aging

Program affiliation
Cancer Biology
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
A major component of my research program is to (1) develop strategies for improving the therapeutic ratio of radiation therapy by increasing tumor sensitivity to radiation and limiting normal tissue toxicity and (2) understand the biological mechanisms of treatment resistance.

Key words
Cancer targeting, antibodies, Translational research, Radiation, Lung Cancer, Glioblastoma, Signaling mechanisms

Program affiliation
Developmental Regenerative and Stem Cell Biology
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding and modifying the mechanisms controlling the onset of melanoma cancer by integrating zebrafish models and human disease

Key words
melanoma, cancer initiation, epigenetics, molecular genetics, neural crest, zebrafish, cancer models

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
clinical and translational research in gynecologic oncology, with a focus on ovarian cancer

Key words

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Neurosciences
Cancer Biology

Research summary
Genetic and epigenetic changes that drive malignant behavior in brain tumors

Key words
brain tumors, glioblastoma, meningioma, neural stem cells

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Cancer Biology

Research summary
My goal is to understand how CAR T cells interact with their immune environment, and to manipulate these interactions to improve outcomes of treatment.

Key words
CAR T cells, HSCs, cell therapy, gene therapy, cancer

Program affiliation
Immunology
Cancer Biology
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
understand the biology of different human dendritic cells and other myeloid cells as a key for manipulating immune responses in various disease conditions

Key words
Human Immunology, Dendritic Cells, Tumor Immunology, immune dysfunctions, Vaccines

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Our laboratory focuses on the fundamental issues of DNA repair and how they relate to cancer initiation, progression, and therapy responses.

Key words
DNA repair, DNA replication