Computational and Systems Biology

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science
Neurosciences
Computational and Systems Biology

Research summary

Key words

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Statistical genetics, complex human diseases, analysis methods

Key words
genetics, substance dependence, addiction, human disease gene mapping, association studies, linkage analysis

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Intersection between visceral sensation, organ function, and emotions

Key words
Visceral Pain, Genomics, Neural Circuits, Emotions

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Pediatric gut microbiome and immune disruption in serious bacterial infections

Key words
Microbiome, sepsis, bacteremia, infectious diseases, immune response, pediatrics

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Understand the structural mechanisms of host-pathogen interactions and the inflammasome signaling

Key words
structural biology, innate immunity, pattern recognition receptors, immune recognition, inflammasomes

Program affiliation
Computational and Systems Biology
Cancer Biology
Biomedical Informatics and Data Science
Neurosciences

Research summary
I have multidisciplinary research interests spanning disease biology, engineering, imaging sciences, and informatics. Our work integrates computational imaging, artificial intelligence, and clinical/translational medicine to discover and validate quantitative imaging biomarkers and to define therapeutic endpoints in cancer and other diseases.

Key words
Computational medicine, cancer, systems biology and quantitative imaging

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Engineering to help cardiac arrhythmia patients feel better and live longer.

Key words
Bioelectricity, Arrhythmias, Modeling, Molecular Imaging, Electrophysiology, Induced Pluripotent Stem Cells

Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding how synthetic antigen receptors direct T cell function and dysfunction in the treatment of blood cancers

Key words
CAR T cell therapy, immunotherapy for cancer, T cell signaling, T cell dysfunction, lineage decisions

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
My research program studies DNA methylation in cancer, with a specific emphasis on understanding the origin, evolution, and functional impact of cancer-associated DNA methylation changes and how these can be used as biomarkers of clinical outcomes.

Key words
epigenetics, methylation, gene regulation, cancer, leukemia, genomics

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
We use multiomic approaches to discover mechanisms underlying cardiovascular disease and leverage these insights to identify new drug targets.

Key words
Human genetics; cardiovascular disease