Computational and Systems Biology

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
My research program studies DNA methylation in cancer, with a specific emphasis on understanding the origin, evolution, and functional impact of cancer-associated DNA methylation changes and how these can be used as biomarkers of clinical outcomes.

Key words
epigenetics, methylation, gene regulation, cancer, leukemia, genomics

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
We use multiomic approaches to discover mechanisms underlying cardiovascular disease and leverage these insights to identify new drug targets.

Key words
Human genetics; cardiovascular disease

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics
Biochemistry Biophysics and Structural Biology

Research summary
Computational biology, bioinformatics, protein-DNA interactions, gene regulation

Key words
computational biology, genome analysis, gene expression, mathematical modeling

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Biomedical Informatics and Data Science
Molecular Genetics and Genomics

Research summary

Key words
protein design, protein engineering, influenza, RSV, machine learning , vaccines, antivirals

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
We computationally model drug metabolism to predict drug toxicity and to assist pathologists in assessing histology images.

Key words
deep learning, metabolism, pathology, image analysis, machine learning, bioinformatics, biostatistics, chemical informatics, drug and target discovery, drug design

Program affiliation
Computational and Systems Biology
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Metabolism analysis and metabolic engineering of environmental microorganisms for biofuel/chemical production

Key words
Metabolic flux analysis, bioenergy, metabolic engineering, algal bioprocess, bioremediation, kinetic modeling

Program affiliation
Neurosciences
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Applying concepts and methods from statistical physics and mathematics to the study of the brain

Key words
theoretical and computational neuroscience, statistical physics

Program affiliation
Computational and Systems Biology
Ecology and Evolutionary Biology

Research summary
Theoretical physics of ecology and evolution; quantitative modeling; analysis of sequencing data

Key words
Theoretical biophysics; Evolution; Microbiome; High-diversity ecology

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology
Ecology and Evolutionary Biology
Biomedical Informatics and Data Science

Research summary
Understanding the genetic basis of root growth and environmental plasticity using phenomics

Key words
imaging; plant; genetics; computation; phenotyping; roots; plant x environment

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Systems-biology approach to study how cells build tissues with precise patterns and shapes in embryo development

Key words