Computational and Systems Biology

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Biomedical Informatics and Data Science
Molecular Genetics and Genomics

Research summary

Key words
protein design, protein engineering, influenza, RSV, machine learning , vaccines, antivirals

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
We computationally model drug metabolism to predict drug toxicity and to assist pathologists in assessing histology images.

Key words
deep learning, metabolism, pathology, image analysis, machine learning, bioinformatics, biostatistics, chemical informatics, drug and target discovery, drug design

Program affiliation
Computational and Systems Biology
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Metabolism analysis and metabolic engineering of environmental microorganisms for biofuel/chemical production

Key words
Metabolic flux analysis, bioenergy, metabolic engineering, algal bioprocess, bioremediation, kinetic modeling

Program affiliation
Neurosciences
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Applying concepts and methods from statistical physics and mathematics to the study of the brain

Key words
theoretical and computational neuroscience, statistical physics

Program affiliation
Computational and Systems Biology
Ecology and Evolutionary Biology

Research summary
Theoretical physics of ecology and evolution; quantitative modeling; analysis of sequencing data

Key words
Theoretical biophysics; Evolution; Microbiome; High-diversity ecology

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology
Ecology and Evolutionary Biology
Biomedical Informatics and Data Science

Research summary
Understanding the genetic basis of root growth and environmental plasticity using phenomics

Key words
imaging; plant; genetics; computation; phenotyping; roots; plant x environment

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Systems-biology approach to study how cells build tissues with precise patterns and shapes in embryo development

Key words

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Molecular Genetics and Genomics
Neurosciences

Research summary
Discovery and characterization of genetic etiological factors involved in neurodevelopmental disorders

Key words
genomics, genetics, autism, neurodevelopmental disorders, complex disease, noncoding, enhancers, whole-genome sequencing, whole-exome sequencing, single-nucleotide variation, insertions/deletions, copy number variation, structural variation

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics
Immunology
Cancer Biology

Research summary
We want to understand how microbes interact with humans so that we can identify new strategies to improve health. Our research integrates 'skinomics', metagenomics and host-microbial genetics to address how microbes influence skin physiology.

Key words
microbiome, skin, dermatology, skin diseases, infection, skin cancer, wound healing, environmental exposures

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Computational and Systems Biology
Plant and Microbial Biosciences

Research summary
Discovery and Characterization of Novel Viruses

Key words
microbial pathogenesis, functional genomics, virology, genome analysis, computational biology