Computational and Systems Biology

Program affiliation
Neurosciences
Computational and Systems Biology

Research summary
Systems analysis of neural information processing; bio-inspired sensors and algorithms

Key words
mathematical modeling, neurobiology, neurophysiology, sensory systems, smell, systems neuroscience

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Using bench molecular biology, high-throughput sequencing, and bioinformatics to understand human inflammatory / autoimmune disease.

Key words
human genetics; autoimmune; inflammatory disease; biomarkers; high-throughput sequencing; precision medicine

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Neurosciences

Research summary
To understand how and why membrane proteins fold, form stable complexes, and achieve conformational stability inside of the oil-filled cell membrane.

Key words
membrane protein; single-molecule; TIRF microscopy; protein folding; thermodynamics; lipids; oligomerization

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Statistical genetics, complex human diseases, analysis methods

Key words
genetics, substance dependence, addiction, human disease gene mapping, association studies, linkage analysis

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Intersection between visceral sensation, organ function, and emotions

Key words
Visceral Pain, Genomics, Neural Circuits, Emotions

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Pediatric gut microbiome and immune disruption in serious bacterial infections

Key words
Microbiome, sepsis, bacteremia, infectious diseases, immune response, pediatrics

Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Understand the structural mechanisms of host-pathogen interactions and the inflammasome signaling

Key words
structural biology, innate immunity, pattern recognition receptors, immune recognition, inflammasomes

Program affiliation
Computational and Systems Biology
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Multi-disciplinary research spanning biology of disease mechanisms, engineering and imaging sciences & informatics

Key words
Computational medicine, cancer, systems biology and quantitative imaging

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Engineering to help cardiac arrhythmia patients feel better and live longer.

Key words
Bioelectricity, Arrhythmias, Modeling, Molecular Imaging, Electrophysiology, Induced Pluripotent Stem Cells

Program affiliation
Immunology
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding how synthetic antigen receptors direct T cell function and dysfunction in the treatment of blood cancers

Key words
CAR T cell therapy, immunotherapy for cancer, T cell signaling, T cell dysfunction, lineage decisions