Computational and Systems Biology
Gary Patti, PhD
Michael and Tana Powell Professor
- Email: gjpattij@wustl.edu
Program affiliation
Cancer Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science
Research summary
To understand the metabolic crosstalk between cells and tissues in disease models such as cancer by using isotopes and metabolomics
Key words
metabolism, metabolomics, mass spectrometry, bioinformatics, imaging, cancer, tumor microenvironment, isotope tracing
Philip Payne, PhD, FACMI
Janet and Bernard Becker Professor
- Email: prpayne@wustl.edu
Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Research summary
Translational Bioinformatics, Clinical Research Informatics
Key words
Biomedical Informatics, Data Science, Data Analytics, Clinical Research, Translational Research
Jennifer Phillips-Cremins, PhD
BJC Investigator and James S. McDonnell Professor
- Email: jennifer.cremins@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Research summary
The Cremins lab integrates molecular and computational biology to elucidate how the genome’s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders.
Key words
chromatin, neuroepigenetics, 3D genome, synaptic plasticity, Alzheimer's, repeat expansion disorders, chromatin-synapse communication, neural connectome, organoids
David Piston, PhD
Edward Mallinckrodt, Jr. Professor and Head of the Department of Cell Biology & Physiology
- Email: piston@wustl.edu
Program affiliation
Molecular Cell Biology
Computational and Systems Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science
Research summary
Studies of the Molecular Pathways of Islet Hormone Secretion
Key words
Diabetes, Biophysics, Systems Biology, Computational Biology, Hyperspectral Imaging, Glucagon
Jay Ponder, PhD
Associate Professor
- Email: ponder@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Research summary
Computational chemistry, protein engineering, theoretical protein structure and folding
Key words
molecular modeling, protein structure, computational chemistry, molecular dynamics simulation, protein engineering
Michael Province, PhD
Professor
- Email: mprovince@wustl.edu
Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Biomedical Informatics and Data Science
Research summary
Mathematical development of new statistical genetics methodology for complex traits
Key words
biostatistics, genetic epidemiology, human genetics, mathematical modeling, statistical genetics, systems biology
Sidharth Puram, MD, PhD
Lindburg Professor and Head of the Department of Otolaryngology
- Email: sidpuram@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Understanding the role of tumor heterogeneity in cancer biology, including its contributions to cancer development, growth, metastasis, and treatment resistance mechanisms, in order to translate these insights into new diagnostics and novel therapeutics
Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling
Baranidharan Raman, PhD
Associate Professor
- Email: barani@seas.wustl.edu
Program affiliation
Neurosciences
Computational and Systems Biology
Research summary
Systems analysis of neural information processing; bio-inspired sensors and algorithms
Key words
mathematical modeling, neurobiology, neurophysiology, sensory systems, smell, systems neuroscience
Elisha Roberson, PhD
Assistant Professor
- Email: eroberson@wustl.edu
Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science
Research summary
Using bench molecular biology, high-throughput sequencing, and bioinformatics to understand human inflammatory / autoimmune disease.
Key words
human genetics; autoimmune; inflammatory disease; biomarkers; high-throughput sequencing; precision medicine
Janice Robertson, PhD
Associate Professor
- Email: janice.robertson@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Computational and Systems Biology
Neurosciences
Research summary
To understand how and why membrane proteins fold, form stable complexes, and achieve conformational stability inside of the oil-filled cell membrane.
Key words
membrane protein; single-molecule; TIRF microscopy; protein folding; thermodynamics; lipids; oligomerization