Computational and Systems Biology

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology
Neurosciences

Research summary
Our research interests include developing innovative computational tools/methods and utilizing single-cell (epi)genomic techniques to gain a comprehensive understanding of gene regulation in mammalian models and human diseases, particularly in brain tumors and neuropsychiatric disorders.

Key words
Bioinformatics, Gene Regulation, Single-cell Epigenetics, Brain Tumors, Neurological Disorders

Program affiliation
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Plant and Microbial Biosciences

Research summary
A computational and experimental lab studying bacterial colonization and transmission at the boundary of built and natural environments and exploring microbiomes as environmental sensors and public health sentinels

Key words

Program affiliation
Cancer Biology
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
Translational Cancer Genomics; Noncoding RNAs

Key words
non-coding RNAs, lncRNAs, cancer genomics, transcriptome, bioinformatics, computational biology, solid tumor malignancies

Program affiliation
Cancer Biology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Studying how perturbation of specific signal transduction pathways contributes to the initiation, progression and dissemination of cancer

Key words
proteomics, functional genomics, lung cancer, signal transduction, WNT, oxidative stress

Program affiliation
Plant and Microbial Biosciences
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
The Mansfeld Lab uses various non‑model species and a hypothesis driven, systems approach to examine how circadian rhythm, development, and tissue type impact plant defense.

Key words
Plant Pathology, Genomics, Bioinformatics, Disease Resistance

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
Development of liquid biopsy approaches for brain tumors

Key words
liquid biopsy, cfDNA, genetics, epigenetics

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Cancer Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the molecular determinants of cellular diversity

Key words
Chromatin, Transcription Factors, Epigenomics, Cell fate, Single-cell

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Technology development for functional genomics and systems biology

Key words
functional genomics, systems biology, technology development, bioinformatics

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Next-generation experimental, multi-omic and computational approaches to empower the study of infectious diseases and the human microbiome

Key words
Genomics of Infectious Diseases, Helminth Genomics, Human Metagenomics

Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology

Research summary
Targeting Enteroendocrine Cell Development to Treat Metabolic Diseases

Key words
Genomics, Single-Cell, Endocrinology, Stem Cells, Gastroenterology, Intestine, Epigenetics