Developmental Regenerative and Stem Cell Biology

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Investigating molecular mechanisms underlying inflammation-induced degenerative skeletal diseases including joint degeneration, inflammatory arthritis and osteolysis

Key words
Musculoskeletal, inflammatory osteolysis, degenerative, bone biology, Signal transduction, NF-kB, Osteoclast, Bone Metabolism, Joint

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding how glia shape developmental and pathological plasticity

Key words
astrocytes, plasticity, circuits, development, myelination

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Respiratory immunobiology, with particular interest in cytokine pathways associated with lung epithelial progenitors

Key words

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
The Riera Lab uses a multidisciplinary approach to investigate how biochemical and biomechanical signaling from the ovary regulates folliculogenesis and oocyte quality, and whether these mechanisms are altered in reproductive-associated diseases such as PCOS and aging.

Key words
Female reproduction, mechanobiology, ovary, folliculogenesis, reproductive aging, oocyte quality

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
Innate immunity and immune effector mechanisms in the retina; oxidative stress and cell death; models of developmental angiogenesis and neovascularization; inflammation and photoreceptor survival; macular degeneration

Key words
aging, Angiogenesis, macular degeneration, diabetes, innate immunity, macrophage, retinal degeneration, vascular biology

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Ocular cell biology

Key words
ophthalmology, cataract, glaucoma, myopia, microfibrils, imaging, stem cells, Marfan syndrome, fibrillin, modeling, AFM

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Identification of new targets to improve tumor radiation effectiveness and to protect normal tissues such as the heart from radiation injury

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Placental and pituitary hormone genes

Key words
biochemistry, carbohydrate, protein structure, signal transduction, intracellular trafficking

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology

Research summary
Structure and physiology of neuronal circuits in mouse visual cortex

Key words
neurobiology, vision, physiology, development, synapse biology

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science

Research summary
We study disease-relevant cell and organ signaling pathways in inflammatory bowel disease using molecular and cell biology, multi-omics technologies, genetic murine models, and patient samples.

Key words
inflammatory bowel disease, mucosal immunity, innate lymphoid cells, human intestinal organoids, regenerative medicine, biomarker discovery, cellular stress response, perianal fistulizing Crohn's disease, eosinophilic esophagitis, colon cancer