Developmental Regenerative and Stem Cell Biology
Douglas Chalker, PhD
Professor
- Email: dchalker@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Developmental Regenerative and Stem Cell Biology
Research summary
Genetic and epigenetic regulation of developmentally programmed DNA rearrangements of Tetrahymena, control of intercellular patterning
Key words
cellular patterning, cell biology, basal bodies and cilia, chromatin structure, development, DNA, genome rearrangements, RNA interference,
Grant Challen, PhD
Professor
- Email: grantchallen@wustl.edu
Program affiliation
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Understanding the genetic and epigenetic mechanisms that regulate normal and leukemic stem cells
Key words
Hematopoietic stem cells, Leukemia stem cells, Epigenetic modifications
David Chen, MD,PhD
Assistant Professor
- Email: davidchen@wustl.edu
Program affiliation
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Research summary
Defining drivers of premalignant states in skin
Key words
epigenetics, aging, cancer, premalignancy, dermatology, melanoma, nevi, squamous cell carcinoma
Feng Chen, PhD
Professor
- Email: fchen@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Cancer Biology
Research summary
Molecular genetic studies of kidney diseases and cancer
Key words
Molecular genetics, kidney diseases, cancer, single cell omics, spatial omics
Shiming Chen, PhD
Dr. Bernard and Janet R. Becker Distinguished Professor
- Email: chenshiming@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences
Research summary
Molecular mechanisms regulating photoreceptor gene expression in healthy and diseased retinas
Key words
Gene expression regulation, transcription factors, epigenetic regulators, photoreceptor development and degeneration, mouse models, gene therapy
Milan Chheda, MD
Associate Professor
- Email: mchheda@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Immunology
Developmental Regenerative and Stem Cell Biology
Research summary
Cancer stem cells, oncolytic viruses, and functional genomics of brain tumors
Key words
Cancer stem cells, oncolytic viruses, and functional genomics of brain tumors
Kyunghee Choi, PhD
Professor
- Email: kchoi@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Cancer Biology
Molecular Cell Biology
Research summary
Angioimmune interface in development, tissue regeneration, and cancer
Key words
Cell fate, transcription factors, hematopoiesis, vascular, development, regeneration, stem cells, tumor angiogenesis, tumor immunity
Matthew Christopher, MD, PhD
Assistant Professor
- Email: christopherm@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Improve outcomes for patients with acute myeloid leukemia (AML) and other hematopoietic malignancies utilizing genomic and molecular biology techniques
Key words
Brian Clark, PhD
Assistant Professor
- Email: brian.s.clark@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Research summary
Genetic and epigenetic control of retinal development and retinal cell fate specification
Key words
Jonathan Cooper, PhD
Professor
- Email: cooperjd@wustl.edu
Program affiliation
Neurosciences
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology
Research summary
Disease mechanisms and treatments for inherited childhood neurodegeneration
Key words
Batten Disease, Neuronal Ceroid Lipofuscinosis, NCL, Lysosomal Storage Disease, pathogenesis, pre-clinical therapies, enzyme replacement, gene therapy