Developmental Regenerative and Stem Cell Biology

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Investigating molecular mechanisms underlying inflammation-induced degenerative skeletal diseases including joint degeneration, inflammatory arthritis and osteolysis

Key words
Musculoskeletal, inflammatory osteolysis, degenerative, bone biology, Signal transduction, NF-kB, Osteoclast, Bone Metabolism, Joint

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding how glia shape developmental and pathological plasticity

Key words
astrocytes, plasticity, circuits, development, myelination

Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis

Research summary
My lab investigates respiratory diseases affecting young children caused by exposure to environmental insults, such as allergen and respiratory syncytial virus. We employ a combination of animal models, human epithelial stem cells, and cryopreserved human lung slices to model these diseases.

Key words
lung development, basal stem cell, allergen, RSV, age

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Respiratory immunobiology, with particular interest in cytokine pathways associated with lung epithelial progenitors

Key words

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
The Amargant i Riera Lab uses a multidisciplinary approach to investigate how biochemical and biomechanical signaling from the ovary regulates folliculogenesis and oocyte quality, and whether these mechanisms are altered in reproductive-associated diseases such as PMOS and aging.

Key words
Female reproduction, mechanobiology, ovary, folliculogenesis, reproductive aging, oocyte quality

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
Our research investigates the role of the innate immune system in the pathogenesis of neurodegenerative diseases and the processes of brain aging, employing stem cell-based platforms and transgenic mouse models to study mechanisms of neuroimmune interactions in the brain.

Key words
Neurodegeneration, Innate Immunity, Aging

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
Innate immunity and immune effector mechanisms in the retina; oxidative stress and cell death; models of developmental angiogenesis and neovascularization; inflammation and photoreceptor survival; macular degeneration

Key words
aging, Angiogenesis, macular degeneration, diabetes, innate immunity, macrophage, retinal degeneration, vascular biology

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Identification of new targets to improve tumor radiation effectiveness and to protect normal tissues such as the heart from radiation injury

Key words

Program affiliation
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
The Brimble lab studies the secondary consequences of viral gene therapy approaches. We primarily interrogate T cell responses arising in patients who have received AAV gene therapy and nucleic acid impurities of viral vector systems. We are also developing novel viral vector delivery systems immunologically distinct from AAV vectors in current clinical use.

Key words
AAV Gene Therapy TCR viral vectors translational

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology

Research summary

Key words