Developmental Regenerative and Stem Cell Biology

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics

Research summary
We study how dynamic transcriptional and epigenetic states regulate multipotent retinal progenitor cell neurogenesis and cell fate specification. Studies focus on identifying novel genes and processes that bias retinal development, including lncRNAs and DNA methylation status, using a suite of genomic tools. Integration of our studies with human genetics seeks to understand how genetic variants contribute to molecular dysfunction and manifest as inherited retinal disease.

Key words
Retina; development, lncRNA, DNA demethylation, transcription factors

Program affiliation
Neurosciences
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology
Molecular Cell Biology

Research summary
Disease mechanisms and treatments for inherited childhood neurodegeneration

Key words
Batten Disease, Neuronal Ceroid Lipofuscinosis, NCL, Lysosomal Storage Disease, pathogenesis, pre-clinical therapies, enzyme replacement, gene therapy

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
We study how different types of neurons encoding somatosensory modalities are assembled into functional circuits in both humans and model organisms.

Key words
pain, circuits, development, optogenetics, imaging, electrophysiology, human

Program affiliation
Molecular Genetics and Genomics
Neurosciences
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
(1) transcriptional networks in the retina; (2) the mechanistic basis of color vision; (3) the cis-regulatory basis of human uniqueness and neuropsychiatric disease

Key words
neurobiology, genomics, transcriptional networks, systems biology, photoreceptors, brain, neuropsychiatric disease, disease, cis-regulation

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
To address the central mandate of gene therapy we engineer adenovirus tropism to allow the achievement of effective gene delivery

Key words
Adenovirus, virotherapy, virus, cancer, gene therapy, vaccine

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
My research aims to understand the lung vascular homeostasis and the pathogenesis of pulmonary diseases using novel animal models, integrated pharmacological approaches, genome editing and single cell RNA-sequencing and spatial transcriptomics.

Key words
cardiovascular, lung, vascular, single cell, spatial transcriptomic

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
My lab is interested in understanding how dysregulation of the Core Binding Factor transcription factor promotes AML development

Key words
hematopoiesis, leukemia, AML, acute myeloid leukemia, CBF, RUNX1, CBFB, core binding factor

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology

Research summary
Neural circuits in development and disease

Key words
axon regeneration, axon degeneration, neurodegeneration, glia, neuronal development and differentiation, neuroinflammation, neuroimmunology, synapse biology, drug screens, metabolism

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Cancer Proteogenomics and Cancer Models

Key words

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology

Research summary

Key words