Developmental Regenerative and Stem Cell Biology

Program affiliation
Biochemistry Biophysics and Structural Biology
Developmental Regenerative and Stem Cell Biology
Plant and Microbial Biosciences

Research summary
Interfaces and adhesions in physiology and nature

Key words
mechanics, physics, interfaces, adhesion, mechanobiology, strain mapping, viscoelasticity

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
Understanding the computational principles that underly brain development, using a combination of experimental and theoretical approaches

Key words

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
The Greenberg lab seeks to understand the molecular and cellular biophysics of heart disease, with the goal of engineering disease models and precision therapeutics

Key words
heart disease, single molecule, optical trapping, cardiac muscle, stem cells, tissue engineering, cytoskeletal molecular motors, mechanobiology, computational modeling, precision medicine

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
Deciphering the molecular mechanisms of epigenetics and how when this goes awry diseases arise

Key words
Epigenetics, Transgenerational, Imprinting, Evolution, Multicellularity, Cancer, Tumorigenesis, Epitranscriptomics

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We work on what induces the inner ear in the first place, how the sensory organs of the ear acquire their exquisite pattern, and whether it will ever be possible to regenerate the sensory hair cells of the inner ear in the deaf and hard-of-hearing.

Key words
inner ear, development, regeneration, sensory neuroscience, balance, deafness, embryo, transcription factors, epigenetics, tunicates, squid

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Immunology

Research summary
Application of stem cells and mechanobiology in the onset, progression, and treatment of osteoarthritis and other joint diseases.

Key words
cartilage, obesity, osteoarthritis, mechanobiology, bioengineering, stem cells, iPSCs

Program affiliation
Neurosciences
Cancer Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology

Research summary
Leveraging neurogenetic disorders to study normal brain development, cancer, and autism

Key words
pediatric brain cancer, brain development, neuroimmunology, cancer neuroscience, autism, hiPSC engineering, genetically engineered mice

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding how the extracellular matrix (ECM) contributes to normal arterial development and how its disruptionleads to abnormal vascular development and disease

Key words
Vascular biology, extracellular matrix, elastin, aneurysms, hypertension

Program affiliation
Immunology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
The Han lab investigates microglia and brain macrophage phenotypes in neurodevelopmental and neurodegenerative contexts through the lens of epigenomics and transcriptomics. 

Key words
microglia, neurodevelopment, epigenetics, transcriptomics, neurodegeneration

Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science

Research summary
Molecular, cellular and circuit analysis of circadian rhythms in mammals

Key words
neurobiology, behavior, imaging, circadian rhythm, glia, brain cancer, potassium channels, neuropeptides, astrocytes, glioblastoma, cancer, developmental biology, computational modeling