Developmental Regenerative and Stem Cell Biology
Lilianna Solnica-Krezel, PhD
Professor and Head of the Department of Developmental Biology
- Email: solnical@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Research summary
Inductive and morphogenetic processes that establish and shape germ layers during vertebrate embryogenesis, using zebrafish and embryonic stem cell models
Key words
Gastrulation, Vertebrate embryogenesis, Patterning, Cell movement, Cell signaling, Morphogenesis, Stem Cells
George Souroullas, PhD
Assistant Professor
- Email: george.souroullas@wustl.edu
Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Understand how epigenetic mechanisms and chromatin dynamics contribute towards the development of cancer.
Key words
Epigenetics, chromatin, cancer, mouse models, lymphoma, melanoma, EZH2, PRC2, H3K27me3
David Spencer, MD, PhD
Associate Professor
- Email: dspencer@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology
Research summary
My research program studies DNA methylation in cancer, with a specific emphasis on understanding the origin, evolution, and functional impact of cancer-associated DNA methylation changes and how these can be used as biomarkers of clinical outcomes.
Key words
epigenetics, methylation, gene regulation, cancer, leukemia, genomics
Stephen Stone, MD
Assistant Professor
- Email: sstone@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Research summary
Work in our lab focuses on the role of insulin resistance in human metabolic diseases. To accomplish this, we focus our efforts on patients with severe insulin resistance syndromes.
Key words
Insulin Resistance, Atypical Diabetes, Pediatric Endocrinology, FGF21, Fibroblast Growth factors
Amber Stratman, PhD
Associate Professor
- Email: a.stratman@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology
Research summary
The Stratman lab is broadly interested in how blood vessels form and stabilize during development, and how changes in these processes affect tissue homeostasis and disease.
Key words
mechanobiology, vascular, endothelial cell, blood flow
Paul Taghert, PhD
Professor
- Email: taghertp@wustl.edu
Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Research summary
Circadian physiology and behavior
Key words
circadian rhythm, neuropeptide, GPCR, 2nd messengers, Drosophila
Thorold Theunissen, PhD
Associate Professor
- Email: t.theunissen@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Immunology
Research summary
Naive pluripotency, trophoblast development, and stem-cell-based embryo models
Key words
Michael Thompson, MD, PhD
Assistant Professor
- Email: thompsonmd@wustl.edu
Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Research summary
Understanding the impact of parental obesity on offspring liver disease and the mechanisms that mediate the development of chronic diseases in adulthood
Key words
Tony Tsai, MD, PhD
Assistant Professor
- Email: tonytsai@wustl.edu
Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Computational and Systems Biology
Research summary
Systems-biology approach to study how cells build tissues with precise patterns and shapes in embryo development
Key words
Fumihiko Urano, MD, PhD
Samuel E. Schechter Professor
- Email: urano@wustl.edu
Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Research summary
Regenerative and Gene Therapy for Wolfram Syndrome, a Prototype Endoplasmic Reticulum Disorder
Key words
Wolfram syndrome, Diabetes, Vision Loss, Hearing Loss, Neurodegeneration, Gene Therapy, Genetics, Endoplasmic Reticulum