Developmental Regenerative and Stem Cell Biology

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understand how epigenetic mechanisms and chromatin dynamics contribute towards the development of cancer.

Key words
Epigenetics, chromatin, cancer, mouse models, lymphoma, melanoma, EZH2, PRC2, H3K27me3

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
My research program studies DNA methylation in cancer, with a specific emphasis on understanding the origin, evolution, and functional impact of cancer-associated DNA methylation changes and how these can be used as biomarkers of clinical outcomes.

Key words
epigenetics, methylation, gene regulation, cancer, leukemia, genomics

Program affiliation
Developmental Regenerative and Stem Cell Biology

Research summary
Work in our lab focuses on the role of insulin resistance in human metabolic diseases. To accomplish this, we focus our efforts on patients with severe insulin resistance syndromes.

Key words
Insulin Resistance, Atypical Diabetes, Pediatric Endocrinology, FGF21, Fibroblast Growth factors

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Biochemistry Biophysics and Structural Biology

Research summary
The Stratman lab is broadly interested in how blood vessels form and stabilize during development, and how changes in these processes affect tissue homeostasis and disease.

Key words
mechanobiology, vascular, endothelial cell, blood flow

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Small‑molecule strategies to reprogram leukemia cells and improve therapy response

Key words
Leukemia, Transcription factors, PU.1, Pharmacology, chemoprotection, hematopoiesis

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Immunology

Research summary
Naive pluripotency, trophoblast development, and stem-cell-based embryo models

Key words

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Computational and Systems Biology

Research summary
Systems-biology approach to study how cells build tissues with precise patterns and shapes in embryo development

Key words

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Regenerative and Gene Therapy for Wolfram Syndrome, a Prototype Endoplasmic Reticulum Disorder

Key words
Wolfram syndrome, Diabetes, Vision Loss, Hearing Loss, Neurodegeneration, Gene Therapy, Genetics, Endoplasmic Reticulum

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology

Research summary
Our lab investigates how non-coding genetic variation controls developmental programs and contributes to human disease and evolutionary change. We focus on congenital structural anomalies, pregnancy complications, and bat wing development, combining mouse genetics, embryo genome engineering, and functional genomics approaches, including in vivo MPRAs, to functionally dissect regulatory elements.

Key words
Enhancers, non-coding regulatory variation, developmental genetics, evolution, GWAS, limb development, placental biology, craniofacial development, functional genomics, MPRA

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Cytokine-mediated tissue feedback loops that maintain homeostasis, and environmental factors that instigate inflammation and fibrosis.

Key words