Developmental Regenerative and Stem Cell Biology

Program affiliation
Developmental Regenerative and Stem Cell Biology

Research summary
Molecular mechanisms of liver injury and regeneration

Key words
liver; regeneration; alpha 1 antitrypsin deficiency; liver disease; aflatoxin; acute liver failure; cell cycle; mouse models; epigenetics; metabolism

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Biomedical Informatics and Data Science
Computational and Systems Biology

Research summary

Key words
retina development, epigenetics, histones

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology

Research summary
Control of germline stem cells and meiotic development in C. elegans

Key words
germ cells, C. elegans, genetics, development, functional genomics

Program affiliation
Molecular Cell Biology
Neurosciences
Developmental Regenerative and Stem Cell Biology

Research summary
Interactions between the nervous system and the skeleton

Key words
bone, diabetes, nerve, neuropathy, neuroskeletal biology, obesity, metabolism, adipose tissue, adipocyte, high-resolution imaging, advanced quantification, RNAseq, regeneration, healing

Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Molecular Genetics and Genomics

Research summary
Regulation of hematopoietic stem cells (HSCs) by inflammation

Key words

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
We use zebrafish as a model for human hearing and balance with the goal of protecting and repairing inner ears from damage.

Key words
zebrafish, sensory neuroscience, hearing, balance, synaptic physiology, regeneration

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Focused on injury, repair, and regeneration of musculoskeletal tissues with the goal to understand the progenitor cell population, signals, and role of inflammation on tissue injury and regeneration at the cellular and molecular level

Key words

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Immunology
Neurosciences

Research summary
My research program integrates cardiovascular physiology, stem cell biology, developmental biology, functional genomics, and cardio-oncology to investigate molecular mechanisms of congenital and acquired cardiovascular diseases. My laboratory specializes in developing innovative protocols for generating authentic cardiovascular cell types from human induced pluripotent stem cells (iPSCs), advancing cardiovascular precision medicine. We aim to bridge basic science and clinical translation through disease modeling, therapeutic target identification, and adverse outcome prevention.

Key words
iPSC, CRISPR, organoid, cardiovascular, precision medicine, cardio-oncology

Program affiliation
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Neurosciences

Research summary
Genetic analysis of neural and muscular development in the Drosophila embryo

Key words
development, neurobiology, cell signaling

Program affiliation
Developmental Regenerative and Stem Cell Biology

Research summary
Inductive and morphogenetic processes that establish and shape germ layers during vertebrate embryogenesis, using zebrafish and embryonic stem cell models

Key words
Gastrulation, Vertebrate embryogenesis, Patterning, Cell movement, Cell signaling, Morphogenesis, Stem Cells