Developmental Regenerative and Stem Cell Biology

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Computational and Systems Biology

Research summary
My research program aims to understand the neural circuits that underlie vocal communication processing and investigate how these circuits are disrupted in neuropsychiatric disorders.

Key words
Auditory System, Neuropsychiatric Disorders, Mouse Models, Communication Processing, Development

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Plant and Microbial Biosciences

Research summary
Mechanisms of reproductive cell regeneration and development

Key words
germline, reproduction, stem cells, regeneration, imaging, scRNAseq

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Cancer Biology

Research summary
Optimizing hematopoietic stem cell transplantation as definitive therapy for non-malignant blood diseases

Key words
sickle cell disease, hematopoietic stem cell transplantation, antibody-based immunotherapy, conditioning, JAK inhibitors, gene editing

Program affiliation
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
The Cremins lab integrates molecular and computational biology to elucidate how the genome’s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders.

Key words
chromatin, neuroepigenetics, 3D genome, synaptic plasticity, Alzheimer's, repeat expansion disorders, chromatin-synapse communication, neural connectome, organoids

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Molecular Mechanisms of Nervous System Longevity and Rejuvenation

Key words
epigenetics, nervous system, DNA repair, aging, rejuvenation

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Immunology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the role of tumor heterogeneity in cancer biology, including its contributions to cancer development, growth, metastasis, and treatment resistance mechanisms, in order to translate these insights into new diagnostics and novel therapeutics

Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Investigate gene regulation during kidney development and disease

Key words

Program affiliation
Molecular Cell Biology
Neurosciences
Developmental Regenerative and Stem Cell Biology

Research summary
Channels: diabetes, obesity and brain disorders

Key words
Diabetes, disease, channels, brain, neurons, hormones, growth, death, obesity, physiology

Program affiliation
Developmental Regenerative and Stem Cell Biology

Research summary
Direct reprogramming of cells into specialized cardiac conduction tissues

Key words
conduction system, reprogramming, heart development, Notch, arrhythmia, regenerative medicine, mouse models

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Cancer Biology
Molecular Cell Biology

Research summary
The Brain Development and Disorders Laboratory investigates how long-range neural circuits are established in the brain, and how neural circuit plasticity affects the function of the cerebral cortex.

Key words
cognitive and behavioral neuroscience, developmental neurobiology, molecular and cellular neuroscience, neurogenetics, cerebral cortex, corpus callosum, glial development, neuronal development, brain wiring, agenesis