Developmental Regenerative and Stem Cell Biology

Program affiliation
Neurosciences
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the molecular and cellular mechanisms underlying tauopathies

Key words
neurodegeneration, neurogenetics, Alzheimer`s disease, frontotemporal dementia, tau, amyloid precursor protein, induced pluripotent stem cells (iPSC), cell and molecular biology, molecular mechanisms

Program affiliation
Developmental Regenerative and Stem Cell Biology
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding and modifying the mechanisms controlling the onset of melanoma cancer by integrating zebrafish models and human disease

Key words
melanoma, cancer initiation, epigenetics, molecular genetics, neural crest, zebrafish, cancer models

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
Visual system neuroscience and vision restoration

Key words
physiology, imaging, behavior, genetic and viral engineering, human neuroscience, vision, repair, mathematical modeling

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Mitochondria and autophagy in ischemic liver injury and liver aging

Key words
mitochondria, liver, fatty liver disease

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Cancer Biology

Research summary
My goal is to understand how CAR T cells interact with their immune environment, and to manipulate these interactions to improve outcomes of treatment.

Key words
CAR T cells, HSCs, cell therapy, gene therapy, cancer

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
We are fundamentally interested in the complex cellular and molecular interactions that take place during joint homeostasis and disease.

Key words
Osteoarthritis, Immunology, Crosstalk, Fibrosis, Inflammation

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
organismal aging; zinc homeostasis and roles of zinc during cell differentiation.

Key words
aging, metals, zinc, development, sperm activation, signal transduction, homeostasis

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Neurosciences

Research summary
Transcriptional and epigenetic regulation of neural development and its dysregulation to cause neurodevelopmental disorders

Key words
human pluripotent stem cell, autism, neuron, neurodevelopmental disorders, cerebral organoid, epigenetic regulation, transcriptional regulation, neurobiology, embryonic stem cell, neural stem cell, transcription, gene regulatory network, chromatin, embryo

Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Molecular Cell Biology

Research summary
Identify signaling pathways that mediate cardiac tissue repair/regeneration and heart failure pathogenesis.

Key words
heart failure, heart development, macrophages, innate immunity

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Microglial biology and neuro-immune interactions in development, aging and disease

Key words
microglia, neuroimmunology, development, aging, neurodegeneration, single cell