Human and Statistical Genetics

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Biomedical Informatics and Data Science
Human and Statistical Genetics

Research summary
We use human genetic, functional genomic, and bioinformatic approaches to understand the consequence of genetic variants underlying diseases

Key words
Functional genomics, bioinformatics, human genetics, data science, rare diseases, pain

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics
Ecology and Evolutionary Biology

Research summary
Integration of whole-genome sequence with phenotypic data to understand parent-of-origin genetic effects and gene-by-environment interactions

Key words
Epigenetics, gene regulation, parent-of-origin effects, gene-by-environment interactions, pleiotropy, systems biology, metabolism, evolution

Program affiliation
Cancer Biology
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics

Research summary
Translational Cancer Genomics; Noncoding RNAs

Key words
non-coding RNAs, lncRNAs, cancer genomics, transcriptome, bioinformatics, computational biology, solid tumor malignancies

Program affiliation
Biomedical Informatics and Data Science
Human and Statistical Genetics
Molecular Genetics and Genomics

Research summary
Develop and implement effective health communication and decision making interventions in community and clinical settings

Key words

Program affiliation
Human and Statistical Genetics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Mathematical development of new statistical genetics methodology for complex traits

Key words
biostatistics, genetic epidemiology, human genetics, mathematical modeling, statistical genetics, systems biology

Program affiliation
Human and Statistical Genetics
Biomedical Informatics and Data Science

Research summary
Statistical genetics; complex disease genetics; methods in statistical genetics

Key words
mathematical modeling, epidemiology, genetics

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
Using bench molecular biology, high-throughput sequencing, and bioinformatics to understand human inflammatory / autoimmune disease.

Key words
human genetics; autoimmune; inflammatory disease; biomarkers; high-throughput sequencing; precision medicine

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
Statistical genetics, complex human diseases, analysis methods

Key words
genetics, substance dependence, addiction, human disease gene mapping, association studies, linkage analysis

Program affiliation
Molecular Cell Biology
Human and Statistical Genetics

Research summary
Skeletal mechanobiology; bone strength; osteoporosis; bone fracture, repair & regeneration

Key words
bone mechanics, bone biology, injury, mechanotransduction, mouse models, osteoporosis

Program affiliation
Human and Statistical Genetics
Molecular Genetics and Genomics
Computational and Systems Biology
Biomedical Informatics and Data Science

Research summary
We use multiomic approaches to discover mechanisms underlying cardiovascular disease and leverage these insights to identify new drug targets.

Key words
Human genetics; cardiovascular disease