Immunology

Program affiliation
Cancer Biology
Immunology
Molecular Cell Biology

Research summary
Advancing knowledge of the mechanisms responsible for colorectal tumor progression, with a specific focus on Stress and its influence on the Tumor Microenvironment.

Key words
Tumor Microenvironment, Stress

Program affiliation
Cancer Biology
Immunology

Research summary
The Herzog Lab at Washington University School of Medicine focuses on understanding the tumor microenvironment (TME) in thoracic malignancies, with a particular emphasis on lung cancer. We combine cutting-edge immunology, genomics, and translational approaches to identify mechanisms of immune evasion and develop novel combination immunotherapy strategies.

Key words
CAFs, Cancer-associated fibroblasts, lung cancer, NSCLC, immunotherapy, cancer immunity

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
New drugs for post-viral and related types of disease

Key words
drug discovery, innate immunity, epithelial stem cells, viruses, respiratory airway disease

Program affiliation
Cancer Biology
Immunology

Research summary
Understanding T cell tolerance to self and non-self

Key words
autoimmunity, immunology, lymphocyte, regulatory T cell, tolerance, mucosal immunology

Program affiliation
Immunology
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary

Key words

Program affiliation
Immunology
Cancer Biology

Research summary
Novel immunotherapeutic strategies to treat solid tumors

Key words

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Immunology

Research summary
Molecular mechanisms of skeletal and cardiac muscle development and disease

Key words
muscle, congenital disease, organogenesis, gene discovery

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Immunology

Research summary
Decoding cell fate decision mechanisms to modulate lineage output for therapeutic purpose

Key words
Hematopoietic stem cells, Multipotent progenitors, Cell fate decision, Lineage specification, Stem cell biology, Cancer (myeloid leukemia), Aging

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Immunology
Molecular Genetics and Genomics

Research summary
We are broadly interested in understanding host/pathogen interactions in malaria parasites. We use a range of approaches including biochemistry, red blood cell genetics and parasite genetics to identify essential ligand/receptor interactions in malaria parasites, with the long-term goal of developing novel therapeutics.

Key words
malaria, red blood cell, plasmodium, ligand/receptor

Program affiliation
Cancer Biology
Molecular Cell Biology
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
A major component of my research program is to (1) develop strategies for improving the therapeutic ratio of radiation therapy by increasing tumor sensitivity to radiation and limiting normal tissue toxicity and (2) understand the biological mechanisms of treatment resistance.

Key words
Cancer targeting, antibodies, Translational research, Radiation, Lung Cancer, Glioblastoma, Signaling mechanisms