Immunology

Program affiliation
Immunology
Developmental Regenerative and Stem Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Understanding how host genetics and environmental factors interact to shape gut metabolism leading to inflammation

Key words

Program affiliation
Cancer Biology
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology
Immunology

Research summary
Cell Motility and Cancer Metastasis

Key words
cell motility, cancer metastasis, cell adhesion, signal transduction

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
The Lopez Lab studies how viruses interact with the body and how defective viruses influence the development of diseases in humans

Key words
virus, respiratory syncytial virus, Sendai virus, innate immunity, antiviral immunity

Program affiliation
Cancer Biology
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
My laboratory studies the pathogenic role of epigenetic regulators in prostate cancer development and progression, with a focus on the mechanisms by which these factors co-operate with transcription factors to drive tumor heterogeneity and resistance to various standard of care therapies

Key words
Epigenetics, prostate cancer, transcriptomics, small molecule therapeutics, radioresistance, DNA damage signaling, tumor-immune dynamics.

Program affiliation
Immunology
Molecular Cell Biology
Cancer Biology

Research summary
Harnessing immune cells to prevent acute graft-versus-host disease

Key words
innate lymphocytes, graft-versus-host disease, cell therapies, cancer

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology
Biochemistry Biophysics and Structural Biology

Research summary
We investigate how host-microbe interactions at epithelial barrier sites impact skin diseases.

Key words
acne, microbiome, cryogenic electron microscopy, cryoEM, crystallography, Cutibacterium acnes, melanoma, immune checkpoint inhibitor, ICI

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Lymphoid tissue dynamics and antigen-presentation during infection, cancer and autoimmunity

Key words
imaging, inflammation, pathogenesis, mathematical modeling, multi-photon microscopy

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis
Molecular Cell Biology

Research summary
Cell biology of the immune system -- understanding how cytoskeletal control of cell motility and adhesion impacts host immunity to infection

Key words
actin cytoskeleton, L-plastin, T cell, B cell, lymphocyte motility, pneumococcal pneumonia,

Program affiliation
Immunology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Our laboratory studies the characteristics and function of human T cells that recognize viral pathogens following vaccination or during acute infection.

Key words
translational research, human immunology, T cell, viral infection, influenza

Program affiliation
Immunology
Cancer Biology

Research summary
Mechanisms of immunotherapy-associated kidney injury and kidney transplant rejection

Key words
Immunology, transplant, oncology, immunotherapy