Molecular Cell Biology

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Investigating molecular mechanisms underlying inflammation-induced degenerative skeletal diseases including joint degeneration, inflammatory arthritis and osteolysis

Key words
Musculoskeletal, inflammatory osteolysis, degenerative, bone biology, Signal transduction, NF-kB, Osteoclast, Bone Metabolism, Joint

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Fatty acids regulate energy balance and tissue renewal. Dysfunction of this regulation causes disease

Key words
fatty acid, transport, disease risk

Program affiliation
Biochemistry Biophysics and Structural Biology
Cancer Biology
Computational and Systems Biology
Molecular Cell Biology

Research summary
The Adhikari Lab focuses on interrogating RAS oncoprotein signaling networks through the lens of interactomes in cancer, based on an innovative functional proteomics platform combining proximity labeling technology coupled to CRISPR/Cas9 screening.

Key words
biochemistry, cell signaling, proteomics, genomics, cancer, tumorigenesis

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Function and modulation of transmitter-gated ion channels

Key words
GABA, ion channel, neurophysiology, nicotinic receptor, pharmacology, structure-function relations

Program affiliation
Neurosciences
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
Understanding the endogenous opioid systems to defeat addiction, ameliorate affective disorders, and relieve chronic pain.

Key words

Program affiliation
Molecular Cell Biology
Developmental Regenerative and Stem Cell Biology

Research summary
The Riera Lab uses a multidisciplinary approach to investigate how biochemical and biomechanical signaling from the ovary regulates folliculogenesis and oocyte quality, and whether these mechanisms are altered in reproductive-associated diseases such as PCOS and aging.

Key words
Female reproduction, mechanobiology, ovary, folliculogenesis, reproductive aging, oocyte quality

Program affiliation
Neurosciences
Developmental, Regenerative and Stem Cell Biology
Molecular Cell Biology
Immunology
Biochemistry, Biophysics, and Structural Biology

Research summary
Our research investigates the role of the innate immune system in the pathogenesis of neurodegenerative diseases and the processes of brain aging, employing stem cell-based platforms and transgenic mouse models to study mechanisms of neuroimmune interactions in the brain.

Key words
Neurodegeneration, Innate Immunity, Aging

Program affiliation
Molecular Genetics and Genomics
Neurosciences
Molecular Cell Biology

Research summary
The Arnold Lab is broadly focused on studying the molecular mechanisms underlying neuronal loss in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other TDP-43 proteinopathies, as well as identifying new biomarkers and therapeutic targets for these disorders.

Key words
neurodegeneration, ALS, neuromuscular, RNA, transcriptomics, biomarker

Program affiliation
Neurosciences
Molecular Cell Biology

Research summary
Uncovering novel regulators of glycolytic and mitochondrial metabolism at the synapse and their role in the pathology of Alzheimer’s disease

Key words

Program affiliation
Immunology
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology

Research summary
Immunometabolism - metabolic regulation of immune cell activation

Key words