Molecular Cell Biology

Program affiliation
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
The molecular mechanisms through which biologic membranes participate in cellular activation processes

Key words
phospholipase A2, diabetes, obesity, receptor, myocardial ischemia, lipid metabolism

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We work on what induces the inner ear in the first place, how the sensory organs of the ear acquire their exquisite pattern, and whether it will ever be possible to regenerate the sensory hair cells of the inner ear in the deaf and hard-of-hearing.

Key words
inner ear, development, regeneration, sensory neuroscience, balance, deafness, embryo, transcription factors, epigenetics, tunicates, squid

Program affiliation
Neurosciences
Molecular Cell Biology
Immunology

Research summary
We develop innovative magnetic resonance (MR) and position emission tomography (PET) imaging approaches to monitor neuroinflammation, neurodegeneration and repair mechanisms in neurological disorders

Key words
Metabolic imaging, hyperpolarized 13C MRI, positron tomography emission (PET) imaging, neurological disorders, cell tracking, multiple sclerosis, microglia, myelin, immune cells

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Immunology

Research summary
Application of stem cells and mechanobiology in the onset, progression, and treatment of osteoarthritis and other joint diseases.

Key words
cartilage, obesity, osteoarthritis, mechanobiology, bioengineering, stem cells, iPSCs

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology
Molecular Genetics and Genomics

Research summary
Understanding how the extracellular matrix (ECM) contributes to normal arterial development and how its disruptionleads to abnormal vascular development and disease

Key words
Vascular biology, extracellular matrix, elastin, aneurysms, hypertension

Program affiliation
Cancer Biology
Molecular Cell Biology

Research summary
The mechanisms of cell death in normal tissues during cancer therapy

Key words
cancer, cell death, drug delivery, radiation, signal transduction

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology

Research summary
Understand the impact of time as a biological variable in the development of critical illness such as sepsis, respiratory failure and chronic inflammatory lung disease

Key words

Program affiliation
Cancer Biology
Immunology

Molecular Cell Biology

Research summary
Advancing knowledge of the mechanisms responsible for colorectal tumor progression, with a specific focus on Stress and its influence on the Tumor Microenvironment.

Key words
Tumor Microenvironment, Stress

Program affiliation
Molecular Cell Biology
Cancer Biology
Biochemistry Biophysics and Structural Biology
Biomedical Informatics and Data Science

Research summary
Redox biochemistry in cell signaling and disease, Proteomics

Key words
proteomics, post-translational modification, cysteine, redox, mass spectrometry, oxidation

Program affiliation
Neurosciences
Computational and Systems Biology
Molecular Cell Biology

Research summary
We take a "big data" approach to understanding the self-organization of neurons and networks in behaving animals.

Key words
Homeostatic plasticity, behavior, neurodegeneration, self-organization, emergence, learning, computational, computation, modeling