Molecular Genetics and Genomics
Brian Muegge, MD, PhD
Assistant Professor
- Email: mueggeb@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Computational and Systems Biology
Molecular Cell Biology
Research summary
Targeting Enteroendocrine Cell Development to Treat Metabolic Diseases
Key words
Genomics, Single-Cell, Endocrinology, Stem Cells, Gastroenterology, Intestine, Epigenetics
Mary Mullen, MD
Assistant Professor
- Email: marymullen@wustl.edu
Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Research summary
Targeting the DNA damage response in order to overcome chemotherapy resistance
Key words
Natalie Niemi, PhD
Assistant Professor
- Email: niemi@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
Understanding how mitochondria are built, regulated, and maintained
Key words
mitochondria, phosphorylation, metabolism, signaling, kinase, phosphatase
Michael Nonet, PhD
Associate Professor
- Email: nonetm@wustl.edu
Program affiliation
Neurosciences
Molecular Genetics and Genomics
Research summary
Molecular genetic analysis of synaptic development and function
Key words
synapse biology, genetics, Zebrafish, C. elegans, exocytosis
Regis O`Keefe, MD, PhD
Fred C Reynolds Professor and Head of the Department of
- Email: rokeefe@wustl.edu
Program affiliation
Molecular Cell Biology
Molecular Genetics and Genomics
Research summary
Cartilage research, bone repair, skeletal development, cancer and inflammatory diseases of bone
Key words
Cartilage research, bone repair, skeletal development, cancer and inflammatory diseases of bone
Stephen Oh, MD, PhD
Professor
- Email: stoh@wustl.edu
Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Immunology
Research summary
Mechanisms of dysregulated signaling in blood cancers
Key words
cancer biology, signal transduction, JAK2, leukemia, hematopoiesis, stem cells, mass cytometry, CyTOF, genomics
Dave Pagliarini, PhD
Hugo F. and Ina C. Urbauer Professor
- Email: pagliarini@wustl.edu
Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology
Research summary
We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.
Key words
Mitochondria, Protein biochemistry, Genetic screening, Metabolism, Biosynthesis, Orphan protein function, Proteomics, Metabolomics, Kinases and phosphates, Metabolic disease, Systems biochemistry
Himadri Pakrasi, PhD
George William and Irene Koechig Freiberg Professor
- Email: pakrasi@wustl.edu
Program affiliation
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics
Research summary
Systems and Synthetic Biology of photosynthetic organisms
Key words
Bioenergy, membrane proteins, photosynthesis, redox processes, systems biology, synthetic biology
Jacqueline Payton, MD, PhD
Associate Professor
- Email: jpayton@wustl.edu
Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Biomedical Informatics and Data Science
Molecular Microbiology and Microbial Pathogenesis
Research summary
Epigenomic aberrations in B cell lymphomas and their impact on gene regulation
Key words
epigenomics, cancer, lymphoma, histone, informatics, genomics, gene regulation
Toby Pennington, DPhil
David and Dorothy Kemper Professor
- Email: ptoby@wustl.edu
Program affiliation
Ecology and Evolutionary Biology
Molecular Genetics and Genomics
Plant and Microbial Biosciences
Research summary
Key words