Molecular Genetics and Genomics

Program affiliation
Cancer Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Immunology

Research summary
Mechanisms of dysregulated signaling in blood cancers

Key words
cancer biology, signal transduction, JAK2, leukemia, hematopoiesis, stem cells, mass cytometry, CyTOF, genomics

Program affiliation
Biochemistry Biophysics and Structural Biology
Molecular Cell Biology
Molecular Genetics and Genomics
Computational and Systems Biology

Research summary
We seek to understand the cellular and biochemical underpinnings of mitochondrial dysfunction in human diseases. Our work integrates large-scale methodologies with traditional biochemistry and cell biology to investigate the modulation, adaptation, and basic metabolic function of mitochondria.

Key words
Mitochondria, Protein biochemistry, Genetic screening, Metabolism, Biosynthesis, Orphan protein function, Proteomics, Metabolomics, Kinases and phosphates, Metabolic disease, Systems biochemistry

Program affiliation
Plant and Microbial Biosciences
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
Systems and Synthetic Biology of photosynthetic organisms

Key words
Bioenergy, membrane proteins, photosynthesis, redox processes, systems biology, synthetic biology

Program affiliation
Molecular Cell Biology
Molecular Microbiology and Microbial Pathogenesis
Biochemistry Biophysics and Structural Biology
Molecular Genetics and Genomics

Research summary
Identifying new targets and possible therapies to treat malaria

Key words
malaria, mRNA surveillance, drug discovery

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Biomedical Informatics and Data Science
Molecular Microbiology and Microbial Pathogenesis

Research summary
Epigenomic aberrations in B cell lymphomas and their impact on gene regulation

Key words
epigenomics, cancer, lymphoma, histone, informatics, genomics, gene regulation

Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics

Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins

Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs

Program affiliation
Immunology
Molecular Genetics and Genomics

Research summary
Immunity and autoimmunity in inflammatory diseases; nanotherapy in the treatment of inflammatory diseases

Key words
autoimmunity, inflammation, innate immunity, nanotechnology, protease

Program affiliation
Biomedical Informatics and Data Science
Human and Statistical Genetics
Molecular Genetics and Genomics

Research summary
Develop and implement effective health communication and decision making interventions in community and clinical settings

Key words

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Molecular Mechanisms of Nervous System Longevity and Rejuvenation

Key words
epigenetics, nervous system, DNA repair, aging, rejuvenation

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the role of tumor heterogeneity in cancer biology, including its contributions to cancer development, growth, metastasis, and treatment resistance mechanisms, in order to translate these insights into new diagnostics and novel therapeutics

Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling