Molecular Genetics and Genomics

Program affiliation
Molecular Cell Biology
Immunology
Molecular Genetics and Genomics

Research summary
Pathobiology of liver disease from accumulation and proteotoxicity of misfolded proteins in α1-antitrypsin deficiency; role of autophagy in biology and treatment of disorders caused by misfolded proteins

Key words
α1-antitrypsin deficiency, protein secretion, protein degradation, autophagy, proteostasis, autophagy enhancer drugs

Program affiliation
Immunology
Molecular Genetics and Genomics

Research summary
Immunity and autoimmunity in inflammatory diseases; nanotherapy in the treatment of inflammatory diseases

Key words
autoimmunity, inflammation, innate immunity, nanotechnology, protease

Program affiliation
Molecular Genetics and Genomics
Neurosciences
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology
Molecular Cell Biology

Research summary
The Cremins lab integrates molecular and computational biology to elucidate how the genome’s structure-function relationship influences synaptic plasticity and neurophysiology during memory encoding and consolidation and how this goes awry in intractable neurological disorders.

Key words
chromatin, neuroepigenetics, 3D genome, synaptic plasticity, Alzheimer's, repeat expansion disorders, chromatin-synapse communication, neural connectome, organoids

Program affiliation
Biomedical Informatics and Data Science
Human and Statistical Genetics
Molecular Genetics and Genomics

Research summary
Develop and implement effective health communication and decision making interventions in community and clinical settings

Key words

Program affiliation
Developmental Regenerative and Stem Cell Biology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Molecular Mechanisms of Nervous System Longevity and Rejuvenation

Key words
epigenetics, nervous system, DNA repair, aging, rejuvenation

Program affiliation
Molecular Genetics and Genomics
Cancer Biology
Computational and Systems Biology
Developmental Regenerative and Stem Cell Biology

Research summary
Understanding the role of tumor heterogeneity in cancer biology, including its contributions to cancer development, growth, metastasis, and treatment resistance mechanisms, in order to translate these insights into new diagnostics and novel therapeutics

Key words
tumor heterogeneity; single cell; spatial transcriptomics; head and neck cancer; signaling

Program affiliation
Ecology and Evolutionary Biology
Plant and Microbial Biosciences
Molecular Genetics and Genomics

Research summary
The evolution of sociality, cooperation, and cheating in a eukaryotic microbe, using experimental evolution, genomics, and other approaches

Key words
social interactions, evolution, microbiology, social amoebae, kin selection, moleuclar evolution, multicellularity, development, genomics

Program affiliation
Cancer Biology
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics

Research summary
Molecular biology and pathogenesis of HIV and HTLV

Key words
lymphocytes, virology, AIDS, leukemia, HIV, HTLV, NF kB

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Investigate gene regulation during kidney development and disease

Key words

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Cancer Biology
Molecular Cell Biology

Research summary
The Brain Development and Disorders Laboratory investigates how long-range neural circuits are established in the brain, and how neural circuit plasticity affects the function of the cerebral cortex.

Key words
cognitive and behavioral neuroscience, developmental neurobiology, molecular and cellular neuroscience, neurogenetics, cerebral cortex, corpus callosum, glial development, neuronal development, brain wiring, agenesis