Molecular Genetics and Genomics

Program affiliation
Immunology
Neurosciences
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
We study complex interactions between the immune and nervous systems in health and disease

Key words
Neuroimmunology; neuroscience; immunology; lymphatics; behavior; Alzheimer’s disease; neurodegeneration; glia; microglia; blood-brain barrier (BBB); meninges

Program affiliation
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics
Molecular Cell Biology
Biochemistry Biophysics and Structural Biology

Research summary
organismal aging; zinc homeostasis and roles of zinc during cell differentiation.

Key words
aging, metals, zinc, development, sperm activation, signal transduction, homeostasis

Program affiliation
Cancer Biology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Our laboratory focuses on the fundamental issues of DNA repair and how they relate to cancer initiation, progression, and therapy responses.

Key words
DNA repair, DNA replication

Program affiliation
Plant and Microbial Biosciences
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics

Research summary
Molecular genetic analysis of disease development in Pseudomonas syringae-Arabidopsis interactions

Key words
plant-microbe interactions, bacterial pathogenesis, auxin, IAA, Type III effector protein, genetics, plant biology

Program affiliation
Ecology and Evolutionary Biology
Computational and Systems Biology
Molecular Genetics and Genomics

Research summary
Modeling the evolution of species with stochastic processes [Recruiting PhD Students for Fall 2024]

Key words
phylogenetics, evolution, ecology, epidemiology, statistical models, stochastic processes, computational inference, deep learning

Program affiliation
Computational and Systems Biology
Molecular Genetics and Genomics
Human and Statistical Genetics
Ecology and Evolutionary Biology

Research summary
Integration of whole-genome sequence with phenotypic data to understand parent-of-origin genetic effects and gene-by-environment interactions

Key words
Epigenetics, gene regulation, parent-of-origin effects, gene-by-environment interactions, pleiotropy, systems biology, metabolism, evolution

Program affiliation
Molecular Genetics and Genomics
Immunology
Cancer Biology

Research summary
Study of normal versus leukemic blood cell development and immunology

Key words
cancer genomics, leukemia, oncogene

Program affiliation
Neurosciences
Developmental Regenerative and Stem Cell Biology
Molecular Genetics and Genomics

Research summary
Microglial biology and neuro-immune interactions in development, aging and disease

Key words
microglia, neuroimmunology, development, aging, neurodegeneration, single cell

Program affiliation
Computational and Systems Biology
Biomedical Informatics and Data Science
Molecular Genetics and Genomics
Cancer Biology
Neurosciences

Research summary
Our research interests include developing innovative computational tools/methods and utilizing single-cell (epi)genomic techniques to gain a comprehensive understanding of gene regulation in mammalian models and human diseases, particularly in brain tumors and neuropsychiatric disorders.

Key words
Bioinformatics, Gene Regulation, Single-cell Epigenetics, Brain Tumors, Neurological Disorders

Program affiliation
Cancer Biology
Immunology
Molecular Genetics and Genomics
Molecular Cell Biology

Research summary
Regulation of normal and malignant hematopoiesis

Key words
Leukemia, clonal hematopoiesis, stem cells, niche, ribosome, cancer metabolism, neutrophils, genomics