Molecular Microbiology and Microbial Pathogenesis

Program affiliation
Developmental Regenerative and Stem Cell Biology
Immunology
Molecular Microbiology and Microbial Pathogenesis

Research summary
My lab investigates respiratory diseases affecting young children caused by exposure to environmental insults, such as allergen and respiratory syncytial virus. We employ a combination of animal models, human epithelial stem cells, and cryopreserved human lung slices to model these diseases.

Key words
lung development, basal stem cell, allergen, RSV, age

Program affiliation
Immunology
Biochemistry Biophysics and Structural Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
Molecular mechanisms at the host-pathogen interface

Key words
biochemistry, structural biology, signaling, virology, host pathogen interactions, immunology

Program affiliation
Neurosciences
Molecular Microbiology and Microbial Pathogenesis
Biomedical Informatics and Data Science

Research summary
Characterization of Dementia (HIV associated neurocognitive disorders (HAND) and Alzheimer`s Disease (AD) using functional magnetic resonance imaging

Key words
Alzheimer’s disease, blood flow, brain mapping, dementia, HIV, MRI

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Molecular Genetics and Genomics
Immunology
Computational and Systems Biology

Research summary
Defining the mechanisms behind and effects of the interactions between commensal bacteria, pathogens and innate immunity

Key words
microbiota, infection, pathogen, microbiome, virus, interferon, immunity

Program affiliation
Plant and Microbial Biosciences
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis

Research summary
Interdisciplinary questions surrounding bacterial small molecule production

Key words
Streptomyces, biosynthesis, genome mining, antibiotics, regulation & genetics

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
Emerging RNA viruses, vaccines, immunology

Key words
Host-pathogen interactions, Influenza virus, SARS-CoV-2, Bourbon virus, Viral pathogenesis, RNA biology, Influenza Reassortment

Program affiliation
Plant and Microbial Biosciences
Molecular Genetics and Genomics
Molecular Microbiology and Microbial Pathogenesis
Computational and Systems Biology

Research summary
Microbial metabolisms and their influence on biogeochemical cycling

Key words

Program affiliation
Immunology
Molecular Cell Biology
Molecular Genetics and Genomics
Developmental Regenerative and Stem Cell Biology
Molecular Microbiology and Microbial Pathogenesis

Research summary
The Brimble lab studies the secondary consequences of viral gene therapy approaches. We primarily interrogate T cell responses arising in patients who have received AAV gene therapy and nucleic acid impurities of viral vector systems. We are also developing novel viral vector delivery systems immunologically distinct from AAV vectors in current clinical use.

Key words
AAV Gene Therapy TCR viral vectors translational

Program affiliation
Molecular Microbiology and Microbial Pathogenesis
Immunology

Research summary
The research in my laboratory is aimed at understanding fundamental principles of the interaction between bacterial pathogens and the human host.

Key words

Program affiliation
Biomedical Informatics and Data Science
Computational and Systems Biology
Molecular Microbiology and Microbial Pathogenesis
Cancer Biology

Research summary
Novel genetic, microbial, and lifestyle risk factors for lung and gastrointestinal cancers leveraging large-scale clinical and population-based cohorts with deep genomic and phenotypic data

Key words
Systems and translational cancer epidemiology, microbiome, inflammation and immune-metabolic networks